Lysosomal acid phosphatase

UniProt data

UniProt name: PPAL_HUMAN (P11117)

Gene name: ACP2

Organism: Homo sapiens (Human).

Function:

Subcellular location: Lysosome membrane {ECO:0000269|PubMed:2684640, ECO:0000269|PubMed:3056714}; Single- pass membrane protein {ECO:0000255}; Lumenal side {ECO:0000305|PubMed:2684640, ECO:0000305|PubMed:3056714}. Lysosome lumen. Note=The soluble form arises by proteolytic processing of the membrane-bound form. {ECO:0000269|PubMed:2684640, ECO:0000269|PubMed:3056714}.

Transmembrane domains:

  1. 381-401, 21 AA, Helical. {ECO:0000255}.

Sequence: 423 AA

10 20 30 40 50 60 MAGKRSGWSR AALLQLLLGV NLVVMPPTRA RSLRFVTLLY RHGDRSPVKT YPKDPYQEEE 70 80 90 100 110 120 WPQGFGQLTK EGMLQHWELG QALRQRYHGF LNTSYHRQEV YVRSTDFDRT LMSAEANLAG 130 140 150 160 170 180 LFPPNGMQRF NPNISWQPIP VHTVPITEDR LLKFPLGPCP RYEQLQNETR QTPEYQNESS 190 200 210 220 230 240 RNAQFLDMVA NETGLTDLTL ETVWNVYDTL FCEQTHGLRL PPWASPQTMQ RLSRLKDFSF 250 260 270 280 290 300 RFLFGIYQQA EKARLQGGVL LAQIRKNLTL MATTSQLPKL LVYSAHDTTL VALQMALDVY 310 320 330 340 350 360 NGEQAPYASC HIFELYQEDS GNFSVEMYFR NESDKAPWPL SLPGCPHRCP LQDFLRLTEP 370 380 390 400 410 420 VVPKDWQQEC QLASGPADTE VIVALAVCGS ILFLLIVLLL TVLFRMQAQP PGYRHVADGE DHA

CATM prediction

The sequence of PPAL_HUMAN returned 1 potential models

The positions at the dimer's interface are highlighted in yellow. The position at the crossing point is highlighted in orange.

# Sequence and interface d θ Z' ω' Score
    380       390       400  
  |    +    |    +    |    		 (Å) (°) (Å) (°)  
Model 1 DTEVIVALAVCGSILFLLIVLLLTVLF 6.9 -55.2° 1.5 45.2 -19.7

Click on the model number to visualize its details below.

MODEL 1 DETAILS

Precited structure:


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Download model 1 structure: PDB, PyMOL session

List of hydrogen bonds:

Donor Acceptor Distance
B, 386, ALA, HA A, 385, LEU, O 3.44Å
B, 389, GLY, HA1 A, 386, ALA, O 2.91Å
B, 390, SER, HA A, 389, GLY, O 3.49Å
A, 386, ALA, HA B, 385, LEU, O 3.44Å
A, 389, GLY, HA1 B, 386, ALA, O 2.91Å
A, 390, SER, HA B, 389, GLY, O 3.49Å