T-cell surface glycoprotein CD8 beta chain

UniProt data

UniProt name: CD8B_HUMAN (P10966)

Gene name: CD8B; Synonyms=CD8B1

Organism: Homo sapiens (Human).

Function: Identifies cytotoxic/suppressor T-cells that interact with MHC class I bearing targets. CD8 is thought to play a role in the process of T-cell mediated killing.

Subcellular location: Isoform 8: Secreted {ECO:0000305}.

Transmembrane domains:

  1. 171-191, 21 AA, Helical. {ECO:0000255}.

Sequence: 210 AA

10 20 30 40 50 60 MRPRLWLLLA AQLTVLHGNS VLQQTPAYIK VQTNKMVMLS CEAKISLSNM RIYWLRQRQA 70 80 90 100 110 120 PSSDSHHEFL ALWDSAKGTI HGEEVEQEKI AVFRDASRFI LNLTSVKPED SGIYFCMIVG 130 140 150 160 170 180 SPELTFGKGT QLSVVDFLPT TAQPTKKSTL KKRVCRLPRP ETQKGPLCSP ITLGLLVAGV 190 200 LVLLVSLGVA IHLCCRRRRA RLRFMKQFYK

CATM prediction

The sequence of CD8B_HUMAN returned 1 potential models

The positions at the dimer's interface are highlighted in yellow. The position at the crossing point is highlighted in orange.

# Sequence and interface d θ Z' ω' Score
    170       180       190  
  |    +    |    +    |    		 (Å) (°) (Å) (°)  
Model 1 CSAITLGLLVAGVLVLLVSLGVAIHLC 7.1 -46.0° 2.7 47.1 -13.8
Prolines* CSPITLGLLVAGVLVLLVSLGVAIHLC          

* Note: this sequence contains Pro residues. CATM substituted them with Ala during the modeling. The positions are marked.

Click on the model number to visualize its details below.

MODEL 1 DETAILS

Precited structure:


Click on the image to enlarge

Download model 1 structure: PDB, PyMOL session

List of hydrogen bonds:

Donor Acceptor Distance
B, 174, GLY, HA1 A, 171, ILE, O 2.95Å
B, 175, LEU, HA A, 174, GLY, O 3.39Å
A, 174, GLY, HA1 B, 171, ILE, O 2.95Å
A, 175, LEU, HA B, 174, GLY, O 3.39Å