T-cell-specific surface glycoprotein CD28

UniProt data

UniProt name: CD28_HUMAN (P10747)

Gene name: CD28

Organism: Homo sapiens (Human).

Function: Involved in T-cell activation, the induction of cell proliferation and cytokine production and promotion of T-cell survival. Enhances the production of IL4 and IL10 in T-cells in conjunction with TCR/CD3 ligation and CD40L costimulation (PubMed:8617933). Isoform 3 enhances CD40L-mediated activation of NF-kappa-B and kinases MAPK8 and PAK2 in T-cells (PubMed:15067037). {ECO:0000269|PubMed:15067037, ECO:0000269|PubMed:8617933}.

Subcellular location: Isoform 3: Cell surface {ECO:0000269|PubMed:15067037}.

Transmembrane domains:

  1. 153-179, 27 AA, Helical. {ECO:0000255}.

Sequence: 220 AA

10 20 30 40 50 60 MLRLLLALNL FPSIQVTGNK ILVKQSPMLV AYDNAVNLSC KYSYNLFSRE FRASLHKGLD 70 80 90 100 110 120 SAVEVCVVYG NYSQQLQVYS KTGFNCDGKL GNESVTFYLQ NLYVNQTDIY FCKIEVMYPP 130 140 150 160 170 180 PYLDNEKSNG TIIHVKGKHL CPSPLFPGPS KPFWVLVVVG GVLACYSLLV TVAFIIFWVR 190 200 210 SKRSRLLHSD YMNMTPRRPG PTRKHYQPYA PPRDFAAYRS

CATM prediction

The sequence of CD28_HUMAN returned 2 potential models

The positions at the dimer's interface are highlighted in yellow. The position at the crossing point is highlighted in orange.

# Sequence and interface d θ Z' ω' Score
  150       160       170       180
|    +    |    +    |    +    |  		 (Å) (°) (Å) (°)  
Model 1 SKAFWVLVVVGGVLACYSLLVTVAFIIFWVRSK 6.7 -55.0° 1.5 44.8 -15.7
Model 2 SKAFWVLVVVGGVLACYSLLVTVAFIIFWVRSK 7.3 -51.6° 2.4 45.1 -13.3
Prolines* SKPFWVLVVVGGVLACYSLLVTVAFIIFWVRSK          

* Note: this sequence contains Pro residues. CATM substituted them with Ala during the modeling. The positions are marked.

Click on the model number to visualize its details below.

MODEL 1 DETAILS

Precited structure:


Click on the image to enlarge

Download model 1 structure: PDB, PyMOL session

List of hydrogen bonds:

Donor Acceptor Distance
B, 157, VAL, HA A, 156, LEU, O 3.26Å
B, 160, GLY, HA1 A, 157, VAL, O 2.63Å
B, 161, GLY, HA2 A, 160, GLY, O 3.08Å
A, 157, VAL, HA B, 156, LEU, O 3.26Å
A, 160, GLY, HA1 B, 157, VAL, O 2.63Å
A, 161, GLY, HA2 B, 160, GLY, O 3.08Å