Receptor-type tyrosine-protein phosphatase F

UniProt data

UniProt name: PTPRF_HUMAN (P10586)

Gene name: PTPRF; Synonyms=LAR

Organism: Homo sapiens (Human).

Function: The first PTPase domain has enzymatic activity, while the second one seems to affect the substrate specificity of the first one.

Subcellular location: Membrane; Single-pass type I membrane protein.

Transmembrane domains:

  1. 1264-1284, 21 AA, Helical. {ECO:0000255}.

Sequence: 1907 AA

10 20 30 40 50 60 MAPEPAPGRT MVPLVPALVM LGLVAGAHGD SKPVFIKVPE DQTGLSGGVA SFVCQATGEP 70 80 90 100 110 120 KPRITWMKKG KKVSSQRFEV IEFDDGAGSV LRIQPLRVQR DEAIYECTAT NSLGEINTSA 130 140 150 160 170 180 KLSVLEEEQL PPGFPSIDMG PQLKVVEKAR TATMLCAAGG NPDPEISWFK DFLPVDPATS 190 200 210 220 230 240 NGRIKQLRSG ALQIESSEES DQGKYECVAT NSAGTRYSAP ANLYVRVRRV APRFSIPPSS 250 260 270 280 290 300 QEVMPGGSVN LTCVAVGAPM PYVKWMMGAE ELTKEDEMPV GRNVLELSNV VRSANYTCVA 310 320 330 340 350 360 ISSLGMIEAT AQVTVKALPK PPIDLVVTET TATSVTLTWD SGNSEPVTYY GIQYRAAGTE 370 380 390 400 410 420 GPFQEVDGVA TTRYSIGGLS PFSEYAFRVL AVNSIGRGPP SEAVRARTGE QAPSSPPRRV 430 440 450 460 470 480 QARMLSASTM LVQWEPPEEP NGLVRGYRVY YTPDSRRPPN AWHKHNTDAG LLTTVGSLLP 490 500 510 520 530 540 GITYSLRVLA FTAVGDGPPS PTIQVKTQQG VPAQPADFQA EVESDTRIQL SWLLPPQERI 550 560 570 580 590 600 IMYELVYWAA EDEDQQHKVT FDPTSSYTLE DLKPDTLYRF QLAARSDMGV GVFTPTIEAR 610 620 630 640 650 660 TAQSTPSAPP QKVMCVSMGS TTVRVSWVPP PADSRNGVIT QYSVAYEAVD GEDRGRHVVD 670 680 690 700 710 720 GISREHSSWD LVGLEKWTEY RVWVRAHTDV GPGPESSPVL VRTDEDVPSG PPRKVEVEPL 730 740 750 760 770 780 NSTAVHVYWK LPVPSKQHGQ IRGYQVTYVR LENGEPRGLP IIQDVMLAEA QWRPEESEDY 790 800 810 820 830 840 ETTISGLTPE TTYSVTVAAY TTKGDGARSK PKIVTTTGAV PGRPTMMIST TAMNTALLQW 850 860 870 880 890 900 HPPKELPGEL LGYRLQYCRA DEARPNTIDF GKDDQHFTVT GLHKGTTYIF RLAAKNRAGL 910 920 930 940 950 960 GEEFEKEIRT PEDLPSGFPQ NLHVTGLTTS TTELAWDPPV LAERNGRIIS YTVVFRDINS 970 980 990 1000 1010 1020 QQELQNITTD TRFTLTGLKP DTTYDIKVRA WTSKGSGPLS PSIQSRTMPV EQVFAKNFRV 1030 1040 1050 1060 1070 1080 AAAMKTSVLL SWEVPDSYKS AVPFKILYNG QSVEVDGHSM RKLIADLQPN TEYSFVLMNR 1090 1100 1110 1120 1130 1140 GSSAGGLQHL VSIRTAPDLL PHKPLPASAY IEDGRFDLSM PHVQDPSLVR WFYIVVVPID 1150 1160 1170 1180 1190 1200 RVGGSMLTPR WSTPEELELD ELLEAIEQGG EEQRRRRRQA ERLKPYVAAQ LDVLPETFTL 1210 1220 1230 1240 1250 1260 GDKKNYRGFY NRPLSPDLSY QCFVLASLKE PMDQKRYASS PYSDEIVVQV TPAQQQEEPE 1270 1280 1290 1300 1310 1320 MLWVTGPVLA VILIILIVIA ILLFKRKRTH SPSSKDEQSI GLKDSLLAHS SDPVEMRRLN 1330 1340 1350 1360 1370 1380 YQTPGMRDHP PIPITDLADN IERLKANDGL KFSQEYESID PGQQFTWENS NLEVNKPKNR 1390 1400 1410 1420 1430 1440 YANVIAYDHS RVILTSIDGV PGSDYINANY IDGYRKQNAY IATQGPLPET MGDFWRMVWE 1450 1460 1470 1480 1490 1500 QRTATVVMMT RLEEKSRVKC DQYWPARGTE TCGLIQVTLL DTVELATYTV RTFALHKSGS 1510 1520 1530 1540 1550 1560 SEKRELRQFQ FMAWPDHGVP EYPTPILAFL RRVKACNPLD AGPMVVHCSA GVGRTGCFIV 1570 1580 1590 1600 1610 1620 IDAMLERMKH EKTVDIYGHV TCMRSQRNYM VQTEDQYVFI HEALLEAATC GHTEVPARNL 1630 1640 1650 1660 1670 1680 YAHIQKLGQV PPGESVTAME LEFKLLASSK AHTSRFISAN LPCNKFKNRL VNIMPYELTR 1690 1700 1710 1720 1730 1740 VCLQPIRGVE GSDYINASFL DGYRQQKAYI ATQGPLAEST EDFWRMLWEH NSTIIVMLTK 1750 1760 1770 1780 1790 1800 LREMGREKCH QYWPAERSAR YQYFVVDPMA EYNMPQYILR EFKVTDARDG QSRTIRQFQF 1810 1820 1830 1840 1850 1860 TDWPEQGVPK TGEGFIDFIG QVHKTKEQFG QDGPITVHCS AGVGRTGVFI TLSIVLERMR 1870 1880 1890 1900 YEGVVDMFQT VKTLRTQRPA MVQTEDQYQL CYRAALEYLG SFDHYAT

CATM prediction

The sequence of PTPRF_HUMAN returned 1 potential models

The positions at the dimer's interface are highlighted in yellow. The position at the crossing point is highlighted in orange.

# Sequence and interface d θ Z' ω' Score
           1270      1280    
    +    |    +    |    +  		 (Å) (°) (Å) (°)  
Model 1 MLWVTGAVLAVILIILIVIAILLFKRK 6.5 -47.0° 2.2 45.0 -18.7
Prolines* MLWVTGPVLAVILIILIVIAILLFKRK          

* Note: this sequence contains Pro residues. CATM substituted them with Ala during the modeling. The positions are marked.

Click on the model number to visualize its details below.

MODEL 1 DETAILS

Precited structure:


Click on the image to enlarge

Download model 1 structure: PDB, PyMOL session

List of hydrogen bonds:

Donor Acceptor Distance
B, 1267, ALA, HA A, 1266, GLY, O 3.05Å
A, 1267, ALA, HA B, 1266, GLY, O 3.05Å