Putative signal peptidase complex catalytic subunit SEC11B

UniProt data

UniProt name: SC11B_HUMAN (P0C7V7)

Gene name: SEC11B; Synonyms=SEC11L2, SPCS4B

Organism: Homo sapiens (Human).

Function: Putative component of some signal peptidase complex which removes signal peptides from nascent proteins as they are translocated into the lumen of the endoplasmic reticulum. {ECO:0000250}.

Subcellular location: Membrane {ECO:0000305}; Single-pass type II membrane protein {ECO:0000305}.

Transmembrane domains:

  1. 7-24, 18 AA, Helical; Signal-anchor for type II membrane protein. {ECO:0000255}.

Sequence: 166 AA

10 20 30 40 50 60 MNKWRLYYQV LNFGMIVSSA LMIWKGLMVI TGSESPIVLL SGSMEPAFHR GYLLFLTNRV 70 80 90 100 110 120 EDPIRVGEIA VLRIEGRKIP IVHRVLKIHE KQNGHIKFLT KGDNNAVDDR GLYKQDQHWL 130 140 150 160 EKKDVVGRAR GFVPYIGIGT SLMNDYPKHK YEVLFLLGLF VLVHRE

CATM prediction

The sequence of SC11B_HUMAN returned 1 potential models

The positions at the dimer's interface are highlighted in yellow. The position at the crossing point is highlighted in orange.

# Sequence and interface d θ Z' ω' Score
        10        20      
 +    |    +    |    +  		 (Å) (°) (Å) (°)  
Model 1 WRLYYQVLNFGMIVSSALMIWKGL 7.2 -44.0° 1.8 45.0 -24.4

Click on the model number to visualize its details below.

MODEL 1 DETAILS

Precited structure:


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Download model 1 structure: PDB, PyMOL session

List of hydrogen bonds:

Donor Acceptor Distance
B, 11, LEU, HA A, 10, VAL, O 3.37Å
B, 14, GLY, HA1 A, 11, LEU, O 3.16Å
B, 15, MET, HA A, 14, GLY, O 3.47Å
B, 18, SER, HG1 A, 15, MET, O 2.51Å
A, 11, LEU, HA B, 10, VAL, O 3.37Å
A, 14, GLY, HA1 B, 11, LEU, O 3.16Å
A, 15, MET, HA B, 14, GLY, O 3.47Å
A, 18, SER, HG1 B, 15, MET, O 2.51Å