Protein ELFN1

UniProt data

UniProt name: ELFN1_HUMAN (P0C7U0)

Gene name: ELFN1; Synonyms=PPP1R28

Organism: Homo sapiens (Human).

Function: Postsynaptic protein that regulates circuit dynamics in the central nervous system by modulating the temporal dynamics of interneuron recruitment. Specifically present in excitatory synapses onto oriens-lacunosum molecular (OLM) interneurons and acts as a regulator of presynaptic release probability to direct the formation of highly facilitating pyramidal-OLM synapses (By similarity). Inhibits phosphatase activity of protein phosphatase 1 (PP1) complexes. {ECO:0000250, ECO:0000269|PubMed:19389623}.

Subcellular location: Membrane {ECO:0000305}; Single-pass type I membrane protein {ECO:0000305}. Cell projection, dendrite {ECO:0000250}. Note=Localizes to excitatory synapses onto somatostatin (Sst)-containing oriens-lacunosum moleculare (O-LM) interneurons. {ECO:0000250}.

Transmembrane domains:

  1. 419-439, 21 AA, Helical. {ECO:0000255}.

Sequence: 828 AA

10 20 30 40 50 60 MAGRGWGALW VCVAAATLLH AGGLARADCW LIEGDKGFVW LAICSQNQPP YEAIPQQINS 70 80 90 100 110 120 TIVDLRLNEN RIRSVQYASL SRFGNLTYLN LTKNEIGYIE DGAFSGQFNL QVLQLGYNRL 130 140 150 160 170 180 RNLTEGMLRG LGKLEYLYLQ ANLIEVVMAS SFWECPNIVN IDLSMNRIQQ LNSGTFAGLA 190 200 210 220 230 240 KLSVCELYSN PFYCSCELLG FLRWLAAFTN ATQTYDRMQC ESPPVYSGYY LLGQGRRGHR 250 260 270 280 290 300 SILSKLQSVC TEDSYAAEVV GPPRPASGRS QPGRSPPPPP PPEPSDMPCA DDECFSGDGT 310 320 330 340 350 360 TPLVALPTLA TQAEARPLIK VKQLTQNSAT ITVQLPSPFH RMYTLEHFNN SKASTVSRLT 370 380 390 400 410 420 KAQEEIRLTN LFTLTNYTYC VVSTSAGLRH NHTCLTICLP RLPSPPGPVP SPSTATHYIM 430 440 450 460 470 480 TILGCLFGMV LVLGAVYYCL RRRRRQEEKH KKAASAAAAG SLKKTIIELK YGPELEAPGL 490 500 510 520 530 540 APLSQGPLLG PEAVTRIPYL PAAGEVEQYK LVESADTPKA SKGSYMEVRT GDPPERRDCE 550 560 570 580 590 600 LGRPGPDSQS SVAEISTIAK EVDKVNQIIN NCIDALKSES TSFQGVKSGP VSVAEPPLVL 610 620 630 640 650 660 LSEPLAAKHG FLAPGYKDAF GHSLQRHHSV EAAGPPRAST SSSGSVRSPR AFRAEAVGVH 670 680 690 700 710 720 KAAAAEAKYI EKGSPAADAI LTVTPAAAVL RAEAEKGRQY GEHRHSYPGS HPAEPPAPPG 730 740 750 760 770 780 PPPPPPHEGL GRKASILEPL TRPRPRDLAY SQLSPQYHSL SYSSSPEYTC RASQSIWERF 790 800 810 820 RLSRRRHKEE EEFMAAGHAL RKKVQFAKDE DLHDILDYWK GVSAQHKS

CATM prediction

The sequence of ELFN1_HUMAN returned 4 potential models

The positions at the dimer's interface are highlighted in yellow. The position at the crossing point is highlighted in orange.

# Sequence and interface d θ Z' ω' Score
      420       430       440
    |    +    |    +    |  		 (Å) (°) (Å) (°)  
Model 1 THYIMTILGCLFGMVLVLGAVYYCLRR 6.5 -48.1° 0.8 53.6 -29.8
Model 2 THYIMTILGCLFGMVLVLGAVYYCLRR 6.9 -54.9° 1.5 44.9 -13.8
Model 3 THYIMTILGCLFGMVLVLGAVYYCLRR 7.2 -45.4° 4.6 38.0 -9.8
Model 4 THYIMTILGCLFGMVLVLGAVYYCLRR 7.4 -45.0° 4.1 39.0 -2.1

Click on the model number to visualize its details below.

MODEL 1 DETAILS

Precited structure:


Click on the image to enlarge

Download model 1 structure: PDB, PyMOL session

List of hydrogen bonds:

Donor Acceptor Distance
B, 421, THR, HA A, 420, MET, O 3.36Å
B, 424, GLY, HA1 A, 421, THR, O 2.89Å
B, 425, CYS, HA A, 424, GLY, O 2.75Å
A, 421, THR, HA B, 420, MET, O 3.36Å
A, 424, GLY, HA1 B, 421, THR, O 2.89Å
A, 425, CYS, HA B, 424, GLY, O 2.75Å