Macrophage colony-stimulating factor 1

UniProt data

UniProt name: CSF1_HUMAN (P09603)

Gene name: CSF1

Organism: Homo sapiens (Human).

Function: Cytokine that plays an essential role in the regulation of survival, proliferation and differentiation of hematopoietic precursor cells, especially mononuclear phagocytes, such as macrophages and monocytes. Promotes the release of proinflammatory chemokines, and thereby plays an important role in innate immunity and in inflammatory processes. Plays an important role in the regulation of osteoclast proliferation and differentiation, the regulation of bone resorption, and is required for normal bone development. Required for normal male and female fertility. Promotes reorganization of the actin cytoskeleton, regulates formation of membrane ruffles, cell adhesion and cell migration. Plays a role in lipoprotein clearance. {ECO:0000269|PubMed:16337366, ECO:0000269|PubMed:19934330, ECO:0000269|PubMed:20504948, ECO:0000269|PubMed:20829061}.

Subcellular location: Processed macrophage colony-stimulating factor 1: Secreted, extracellular space.

Transmembrane domains:

  1. 497-517, 21 AA, Helical. {ECO:0000255}.

Sequence: 554 AA

10 20 30 40 50 60 MTAPGAAGRC PPTTWLGSLL LLVCLLASRS ITEEVSEYCS HMIGSGHLQS LQRLIDSQME 70 80 90 100 110 120 TSCQITFEFV DQEQLKDPVC YLKKAFLLVQ DIMEDTMRFR DNTPNAIAIV QLQELSLRLK 130 140 150 160 170 180 SCFTKDYEEH DKACVRTFYE TPLQLLEKVK NVFNETKNLL DKDWNIFSKN CNNSFAECSS 190 200 210 220 230 240 QDVVTKPDCN CLYPKAIPSS DPASVSPHQP LAPSMAPVAG LTWEDSEGTE GSSLLPGEQP 250 260 270 280 290 300 LHTVDPGSAK QRPPRSTCQS FEPPETPVVK DSTIGGSPQP RPSVGAFNPG MEDILDSAMG 310 320 330 340 350 360 TNWVPEEASG EASEIPVPQG TELSPSRPGG GSMQTEPARP SNFLSASSPL PASAKGQQPA 370 380 390 400 410 420 DVTGTALPRV GPVRPTGQDW NHTPQKTDHP SALLRDPPEP GSPRISSLRP QGLSNPSTLS 430 440 450 460 470 480 AQPQLSRSHS SGSVLPLGEL EGRRSTRDRR SPAEPEGGPA SEGAARPLPR FNSVPLTDTG 490 500 510 520 530 540 HERQSEGSFS PQLQESVFHL LVPSVILVLL AVGGLLFYRW RRRSHQEPQR ADSPLEQPEG 550 SPLTQDDRQV ELPV

CATM prediction

The sequence of CSF1_HUMAN returned 1 potential models

The positions at the dimer's interface are highlighted in yellow. The position at the crossing point is highlighted in orange.

# Sequence and interface d θ Z' ω' Score
        500       510       5
 +    |    +    |    +    |		 (Å) (°) (Å) (°)  
Model 1 QESVFHLLVASVILVLLAVGGLLFYRW 7.1 -43.3° -0.0 34.1 -22.9
Prolines* QESVFHLLVPSVILVLLAVGGLLFYRW          

* Note: this sequence contains Pro residues. CATM substituted them with Ala during the modeling. The positions are marked.

Click on the model number to visualize its details below.

MODEL 1 DETAILS

Precited structure:


Click on the image to enlarge

Download model 1 structure: PDB, PyMOL session

List of hydrogen bonds:

Donor Acceptor Distance
B, 513, GLY, HA1 A, 510, LEU, O 3.44Å
B, 514, GLY, HA2 A, 513, GLY, O 3.23Å
A, 513, GLY, HA1 B, 510, LEU, O 3.44Å
A, 514, GLY, HA2 B, 513, GLY, O 3.23Å