Monoacylglycerol lipase ABHD2 {ECO:0000305}

UniProt data

UniProt name: ABHD2_HUMAN (P08910)

Gene name: ABHD2 {ECO:0000312|HGNC:HGNC:18717}

Organism: Homo sapiens (Human).

Function: Progesterone-dependent acylglycerol lipase that catalyzes hydrolysis of endocannabinoid arachidonoylglycerol (AG) from cell membrane (PubMed:26989199). Acts as a progesterone receptor: progesterone-binding activates the acylglycerol lipase activity, mediating degradation of 1-arachidonoylglycerol (1AG) and 2-arachidonoylglycerol (2AG) to glycerol and arachidonic acid (AA) (PubMed:26989199). Plays a key role in sperm capacitation in response to progesterone by mediating degradation of 2AG, an inhibitor of the sperm calcium channel CatSper, leading to calcium influx via CatSper and sperm activation (PubMed:26989199). May also play a role in smooth muscle cells migration (By similarity). {ECO:0000250|UniProtKB:Q9QXM0, ECO:0000269|PubMed:26989199}.

Subcellular location: Cell projection, cilium, flagellum membrane {ECO:0000305|PubMed:26989199}; Single-pass type II membrane protein {ECO:0000305}. Cell membrane {ECO:0000305}; Single-pass type II membrane protein {ECO:0000305}.

Transmembrane domains:

  1. 10-30, 21 AA, Helical; Signal-anchor for type II membrane protein. {ECO:0000255}.

Sequence: 425 AA

10 20 30 40 50 60 MNAMLETPEL PAVFDGVKLA AVAAVLYVIV RCLNLKSPTA PPDLYFQDSG LSRFLLKSCP 70 80 90 100 110 120 LLTKEYIPPL IWGKSGHIQT ALYGKMGRVR SPHPYGHRKF ITMSDGATST FDLFEPLAEH 130 140 150 160 170 180 CVGDDITMVI CPGIANHSEK QYIRTFVDYA QKNGYRCAVL NHLGALPNIE LTSPRMFTYG 190 200 210 220 230 240 CTWEFGAMVN YIKKTYPLTQ LVVVGFSLGG NIVCKYLGET QANQEKVLCC VSVCQGYSAL 250 260 270 280 290 300 RAQETFMQWD QCRRFYNFLM ADNMKKIILS HRQALFGDHV KKPQSLEDTD LSRLYTATSL 310 320 330 340 350 360 MQIDDNVMRK FHGYNSLKEY YEEESCMRYL HRIYVPLMLV NAADDPLVHE SLLTIPKSLS 370 380 390 400 410 420 EKRENVMFVL PLHGGHLGFF EGSVLFPEPL TWMDKLVVEY ANAICQWERN KLQCSDTEQV EADLE

CATM prediction

The sequence of ABHD2_HUMAN returned 1 potential models

The positions at the dimer's interface are highlighted in yellow. The position at the crossing point is highlighted in orange.

# Sequence and interface d θ Z' ω' Score
     10        20        30  
   |    +    |    +    |   		 (Å) (°) (Å) (°)  
Model 1 TAELAAVFDGVKLAAVAAVLYVIVRCL 6.9 -46.3° 2.7 47.0 -34.2
Prolines* TPELPAVFDGVKLAAVAAVLYVIVRCL          

* Note: this sequence contains Pro residues. CATM substituted them with Ala during the modeling. The positions are marked.

Click on the model number to visualize its details below.

MODEL 1 DETAILS

Precited structure:


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Download model 1 structure: PDB, PyMOL session

List of hydrogen bonds:

Donor Acceptor Distance
B, 13, VAL, HA A, 12, ALA, O 2.92Å
B, 16, GLY, HA1 A, 13, VAL, O 2.87Å
B, 17, VAL, HA A, 16, GLY, O 3.47Å
A, 13, VAL, HA B, 12, ALA, O 2.92Å
A, 16, GLY, HA1 B, 13, VAL, O 2.87Å
A, 17, VAL, HA B, 16, GLY, O 3.47Å