Interleukin-6 receptor subunit alpha

UniProt data

UniProt name: IL6RA_HUMAN (P08887)

Gene name: IL6R

Organism: Homo sapiens (Human).

Function: Low concentration of a soluble form of IL6 receptor acts as an agonist of IL6 activity.

Subcellular location: Isoform 2: Secreted.

Transmembrane domains:

  1. 366-386, 21 AA, Helical. {ECO:0000255}.

Sequence: 468 AA

10 20 30 40 50 60 MLAVGCALLA ALLAAPGAAL APRRCPAQEV ARGVLTSLPG DSVTLTCPGV EPEDNATVHW 70 80 90 100 110 120 VLRKPAAGSH PSRWAGMGRR LLLRSVQLHD SGNYSCYRAG RPAGTVHLLV DVPPEEPQLS 130 140 150 160 170 180 CFRKSPLSNV VCEWGPRSTP SLTTKAVLLV RKFQNSPAED FQEPCQYSQE SQKFSCQLAV 190 200 210 220 230 240 PEGDSSFYIV SMCVASSVGS KFSKTQTFQG CGILQPDPPA NITVTAVARN PRWLSVTWQD 250 260 270 280 290 300 PHSWNSSFYR LRFELRYRAE RSKTFTTWMV KDLQHHCVIH DAWSGLRHVV QLRAQEEFGQ 310 320 330 340 350 360 GEWSEWSPEA MGTPWTESRS PPAENEVSTP MQALTTNKDD DNILFRDSAN ATSLPVQDSS 370 380 390 400 410 420 SVPLPTFLVA GGSLAFGTLL CIAIVLRFKK TWKLRALKEG KTSMHPPYSL GQLVPERPRP 430 440 450 460 TPVLVPLISP PVSPSSLGSD NTSSHNRPDA RDPRSPYDIS NTDYFFPR

CATM prediction

The sequence of IL6RA_HUMAN returned 3 potential models

The positions at the dimer's interface are highlighted in yellow. The position at the crossing point is highlighted in orange.

# Sequence and interface d θ Z' ω' Score
         370       380       
  +    |    +    |    +    		 (Å) (°) (Å) (°)  
Model 1 ALATFLVAGGSLAFGTLLCIAIVLRFK 7.3 -41.0° 3.5 38.1 -25.1
Model 2 ALATFLVAGGSLAFGTLLCIAIVLRFK 7.0 -54.9° 0.3 44.8 -14.1
Model 3 ALATFLVAGGSLAFGTLLCIAIVLRFK 7.1 -53.0° 1.9 45.3 -3.5
Prolines* PLPTFLVAGGSLAFGTLLCIAIVLRFK          

* Note: this sequence contains Pro residues. CATM substituted them with Ala during the modeling. The positions are marked.

Click on the model number to visualize its details below.

MODEL 1 DETAILS

Precited structure:


Click on the image to enlarge

Download model 1 structure: PDB, PyMOL session

List of hydrogen bonds:

Donor Acceptor Distance
B, 370, ALA, HA A, 373, SER, OG 3.13Å
B, 374, LEU, HA A, 373, SER, O 3.27Å
B, 377, GLY, HA1 A, 374, LEU, O 3.31Å
A, 370, ALA, HA B, 373, SER, OG 3.13Å
A, 374, LEU, HA B, 373, SER, O 3.27Å
A, 377, GLY, HA1 B, 374, LEU, O 3.31Å