Low affinity immunoglobulin gamma Fc region receptor III-A

UniProt data

UniProt name: FCG3A_HUMAN (P08637)

Gene name: FCGR3A; Synonyms=CD16A, FCG3, FCGR3, IGFR3

Organism: Homo sapiens (Human).

Function: Receptor for the Fc region of IgG. Binds complexed or aggregated IgG and also monomeric IgG. Mediates antibody-dependent cellular cytotoxicity (ADCC) and other antibody-dependent responses, such as phagocytosis. {ECO:0000269|PubMed:21768335, ECO:0000269|PubMed:22023369}.

Subcellular location: Cell membrane {ECO:0000305}; Single-pass type I membrane protein {ECO:0000305}. Secreted. Note=Exists also as a soluble receptor.

Transmembrane domains:

  1. 209-229, 21 AA, Helical. {ECO:0000255}.

Sequence: 254 AA

10 20 30 40 50 60 MWQLLLPTAL LLLVSAGMRT EDLPKAVVFL EPQWYRVLEK DSVTLKCQGA YSPEDNSTQW 70 80 90 100 110 120 FHNESLISSQ ASSYFIDAAT VDDSGEYRCQ TNLSTLSDPV QLEVHIGWLL LQAPRWVFKE 130 140 150 160 170 180 EDPIHLRCHS WKNTALHKVT YLQNGKGRKY FHHNSDFYIP KATLKDSGSY FCRGLFGSKN 190 200 210 220 230 240 VSSETVNITI TQGLAVSTIS SFFPPGYQVS FCLVMVLLFA VDTGLYFSVK TNIRSSTRDW 250 KDHKFKWRKD PQDK

CATM prediction

The sequence of FCG3A_HUMAN returned 1 potential models

The positions at the dimer's interface are highlighted in yellow. The position at the crossing point is highlighted in orange.

# Sequence and interface d θ Z' ω' Score
      210       220       230
    |    +    |    +    |  		 (Å) (°) (Å) (°)  
Model 1 GYQVSFCLVMVLLFAVDTGLYFSVKTN 7.1 -51.0° 3.3 48.1 -5.6

Click on the model number to visualize its details below.

MODEL 1 DETAILS

Precited structure:


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Download model 1 structure: PDB, PyMOL session

List of hydrogen bonds:

Donor Acceptor Distance
B, 221, VAL, HA A, 220, ALA, O 3.07Å
B, 224, GLY, HA1 A, 221, VAL, O 3.13Å
A, 221, VAL, HA B, 220, ALA, O 3.07Å
A, 224, GLY, HA1 B, 221, VAL, O 3.13Å