Integrin alpha-IIb

UniProt data

UniProt name: ITA2B_HUMAN (P08514)

Gene name: ITGA2B; Synonyms=GP2B, ITGAB

Organism: Homo sapiens (Human).

Function: Integrin alpha-IIb/beta-3 is a receptor for fibronectin, fibrinogen, plasminogen, prothrombin, thrombospondin and vitronectin. It recognizes the sequence R-G-D in a wide array of ligands. It recognizes the sequence H-H-L-G-G-G-A-K-Q-A-G-D-V in fibrinogen gamma chain. Following activation integrin alpha- IIb/beta-3 brings about platelet/platelet interaction through binding of soluble fibrinogen. This step leads to rapid platelet aggregation which physically plugs ruptured endothelial cell surface.

Subcellular location: Membrane; Single-pass type I membrane protein.

Transmembrane domains:

  1. 994-1019, 26 AA, Helical. {ECO:0000255}.

Sequence: 1039 AA

10 20 30 40 50 60 MARALCPLQA LWLLEWVLLL LGPCAAPPAW ALNLDPVQLT FYAGPNGSQF GFSLDFHKDS 70 80 90 100 110 120 HGRVAIVVGA PRTLGPSQEE TGGVFLCPWR AEGGQCPSLL FDLRDETRNV GSQTLQTFKA 130 140 150 160 170 180 RQGLGASVVS WSDVIVACAP WQHWNVLEKT EEAEKTPVGS CFLAQPESGR RAEYSPCRGN 190 200 210 220 230 240 TLSRIYVEND FSWDKRYCEA GFSSVVTQAG ELVLGAPGGY YFLGLLAQAP VADIFSSYRP 250 260 270 280 290 300 GILLWHVSSQ SLSFDSSNPE YFDGYWGYSV AVGEFDGDLN TTEYVVGAPT WSWTLGAVEI 310 320 330 340 350 360 LDSYYQRLHR LRGEQMASYF GHSVAVTDVN GDGRHDLLVG APLYMESRAD RKLAEVGRVY 370 380 390 400 410 420 LFLQPRGPHA LGAPSLLLTG TQLYGRFGSA IAPLGDLDRD GYNDIAVAAP YGGPSGRGQV 430 440 450 460 470 480 LVFLGQSEGL RSRPSQVLDS PFPTGSAFGF SLRGAVDIDD NGYPDLIVGA YGANQVAVYR 490 500 510 520 530 540 AQPVVKASVQ LLVQDSLNPA VKSCVLPQTK TPVSCFNIQM CVGATGHNIP QKLSLNAELQ 550 560 570 580 590 600 LDRQKPRQGR RVLLLGSQQA GTTLNLDLGG KHSPICHTTM AFLRDEADFR DKLSPIVLSL 610 620 630 640 650 660 NVSLPPTEAG MAPAVVLHGD THVQEQTRIV LDCGEDDVCV PQLQLTASVT GSPLLVGADN 670 680 690 700 710 720 VLELQMDAAN EGEGAYEAEL AVHLPQGAHY MRALSNVEGF ERLICNQKKE NETRVVLCEL 730 740 750 760 770 780 GNPMKKNAQI GIAMLVSVGN LEEAGESVSF QLQIRSKNSQ NPNSKIVLLD VPVRAEAQVE 790 800 810 820 830 840 LRGNSFPASL VVAAEEGERE QNSLDSWGPK VEHTYELHNN GPGTVNGLHL SIHLPGQSQP 850 860 870 880 890 900 SDLLYILDIQ PQGGLQCFPQ PPVNPLKVDW GLPIPSPSPI HPAHHKRDRR QIFLPEPEQP 910 920 930 940 950 960 SRLQDPVLVS CDSAPCTVVQ CDLQEMARGQ RAMVTVLAFL WLPSLYQRPL DQFVLQSHAW 970 980 990 1000 1010 1020 FNVSSLPYAV PPLSLPRGEA QVWTQLLRAL EERAIPIWWV LVGVLGGLLL LTILVLAMWK 1030 VGFFKRNRPP LEEDDEEGE

CATM prediction

The sequence of ITA2B_HUMAN returned 2 potential models

The positions at the dimer's interface are highlighted in yellow. The position at the crossing point is highlighted in orange.

# Sequence and interface d θ Z' ω' Score
           1000      1010      102
    +    |    +    |    +    |  		 (Å) (°) (Å) (°)  
Model 1 EERAIAIWWVLVGVLGGLLLLTILVLAMWKVG 7.0 -51.8° 1.3 57.0 -30.5
Model 2 EERAIAIWWVLVGVLGGLLLLTILVLAMWKVG 6.8 -53.7° 2.5 33.2 -29.5
Prolines* EERAIPIWWVLVGVLGGLLLLTILVLAMWKVG          

* Note: this sequence contains Pro residues. CATM substituted them with Ala during the modeling. The positions are marked.

Click on the model number to visualize its details below.

MODEL 1 DETAILS

Precited structure:


Click on the image to enlarge

Download model 1 structure: PDB, PyMOL session

List of hydrogen bonds:

Donor Acceptor Distance
B, 1000, VAL, HA A, 999, TRP, O 3.23Å
B, 1003, GLY, HA1 A, 1000, VAL, O 2.98Å
A, 1000, VAL, HA B, 999, TRP, O 3.23Å
A, 1003, GLY, HA1 B, 1000, VAL, O 2.98Å