Tumor necrosis factor receptor superfamily member 16

UniProt data

UniProt name: TNR16_HUMAN (P08138)

Gene name: NGFR; Synonyms=TNFRSF16

Organism: Homo sapiens (Human).

Function: Plays a role in the regulation of the translocation of GLUT4 to the cell surface in adipocytes and skeletal muscle cells in response to insulin, probably by regulating RAB31 activity, and thereby contributes to the regulation of insulin-dependent glucose uptake (By similarity). Low affinity receptor which can bind to NGF, BDNF, NT-3, and NT-4. Can mediate cell survival as well as cell death of neural cells. Necessary for the circadian oscillation of the clock genes ARNTL/BMAL1, PER1, PER2 and NR1D1 in the suprachiasmatic nucleus (SCN) of the brain and in liver and of the genes involved in glucose and lipid metabolism in the liver. {ECO:0000250, ECO:0000269|PubMed:14966521, ECO:0000269|PubMed:23785138}.

Subcellular location: Membrane; Single-pass type I membrane protein.

Transmembrane domains:

  1. 251-272, 22 AA, Helical. {ECO:0000255}.

Sequence: 427 AA

10 20 30 40 50 60 MGAGATGRAM DGPRLLLLLL LGVSLGGAKE ACPTGLYTHS GECCKACNLG EGVAQPCGAN 70 80 90 100 110 120 QTVCEPCLDS VTFSDVVSAT EPCKPCTECV GLQSMSAPCV EADDAVCRCA YGYYQDETTG 130 140 150 160 170 180 RCEACRVCEA GSGLVFSCQD KQNTVCEECP DGTYSDEANH VDPCLPCTVC EDTERQLREC 190 200 210 220 230 240 TRWADAECEE IPGRWITRST PPEGSDSTAP STQEPEAPPE QDLIASTVAG VVTTVMGSSQ 250 260 270 280 290 300 PVVTRGTTDN LIPVYCSILA AVVVGLVAYI AFKRWNSCKQ NKQGANSRPV NQTPPPEGEK 310 320 330 340 350 360 LHSDSGISVD SQSLHDQQPH TQTASGQALK GDGGLYSSLP PAKREEVEKL LNGSAGDTWR 370 380 390 400 410 420 HLAGELGYQP EHIDSFTHEA CPVRALLASW ATQDSATLDA LLAALRRIQR ADLVESLCSE STATSPV

CATM prediction

The sequence of TNR16_HUMAN returned 1 potential models

The positions at the dimer's interface are highlighted in yellow. The position at the crossing point is highlighted in orange.

# Sequence and interface d θ Z' ω' Score
    250       260       270   
  |    +    |    +    |    +		 (Å) (°) (Å) (°)  
Model 1 TDNLIAVYCSILAAVVVGLVAYIAFKRW 7.3 -54.3° 3.6 49.1 -25.6
Prolines* TDNLIPVYCSILAAVVVGLVAYIAFKRW          

* Note: this sequence contains Pro residues. CATM substituted them with Ala during the modeling. The positions are marked.

Click on the model number to visualize its details below.

MODEL 1 DETAILS

Precited structure:


Click on the image to enlarge

Download model 1 structure: PDB, PyMOL session

List of hydrogen bonds:

Donor Acceptor Distance
B, 262, VAL, HA A, 261, ALA, O 3.21Å
B, 265, GLY, HA1 A, 262, VAL, O 3.35Å
A, 262, VAL, HA B, 261, ALA, O 3.21Å
A, 265, GLY, HA1 B, 262, VAL, O 3.35Å