T-cell surface antigen CD2

UniProt data

UniProt name: CD2_HUMAN (P06729)

Gene name: CD2; Synonyms=SRBC

Organism: Homo sapiens (Human).

Function: CD2 interacts with lymphocyte function-associated antigen (LFA-3) and CD48/BCM1 to mediate adhesion between T-cells and other cell types. CD2 is implicated in the triggering of T- cells, the cytoplasmic domain is implicated in the signaling function.

Subcellular location: Membrane; Single-pass type I membrane protein.

Transmembrane domains:

  1. 210-235, 26 AA, Helical. {ECO:0000255}.

Sequence: 351 AA

10 20 30 40 50 60 MSFPCKFVAS FLLIFNVSSK GAVSKEITNA LETWGALGQD INLDIPSFQM SDDIDDIKWE 70 80 90 100 110 120 KTSDKKKIAQ FRKEKETFKE KDTYKLFKNG TLKIKHLKTD DQDIYKVSIY DTKGKNVLEK 130 140 150 160 170 180 IFDLKIQERV SKPKISWTCI NTTLTCEVMN GTDPELNLYQ DGKHLKLSQR VITHKWTTSL 190 200 210 220 230 240 SAKFKCTAGN KVSKESSVEP VSCPEKGLDI YLIIGICGGG SLLMVFVALL VFYITKRKKQ 250 260 270 280 290 300 RSRRNDEELE TRAHRVATEE RGRKPHQIPA STPQNPATSQ HPPPPPGHRS QAPSHRPPPP 310 320 330 340 350 GHRVQHQPQK RPPAPSGTQV HQQKGPPLPR PRVQPKPPHG AAENSLSPSS N

CATM prediction

The sequence of CD2_HUMAN returned 4 potential models

The positions at the dimer's interface are highlighted in yellow. The position at the crossing point is highlighted in orange.

# Sequence and interface d θ Z' ω' Score
     210       220       230      
   |    +    |    +    |    +   		 (Å) (°) (Å) (°)  
Model 1 GLDIYLIIGICGGGSLLMVFVALLVFYITKRK 7.3 -51.6° 2.4 44.7 -19.7
Model 2 GLDIYLIIGICGGGSLLMVFVALLVFYITKRK 6.9 -53.8° 3.6 48.9 -18.0
Model 3 GLDIYLIIGICGGGSLLMVFVALLVFYITKRK 6.9 -54.2° 2.5 33.0 -17.1
Model 4 GLDIYLIIGICGGGSLLMVFVALLVFYITKRK 7.3 -55.0° 2.4 48.3 -3.0

Click on the model number to visualize its details below.

MODEL 1 DETAILS

Precited structure:


Click on the image to enlarge

Download model 1 structure: PDB, PyMOL session

List of hydrogen bonds:

Donor Acceptor Distance
B, 217, CYS, HA A, 216, ILE, O 3.35Å
B, 220, GLY, HA1 A, 217, CYS, O 3.12Å
A, 217, CYS, HA B, 216, ILE, O 3.35Å
A, 220, GLY, HA1 B, 217, CYS, O 3.12Å