HLA class II histocompatibility antigen, DO alpha chain

UniProt data

UniProt name: DOA_HUMAN (P06340)

Gene name: HLA-DOA; Synonyms=HLA-DNA, HLA-DZA

Organism: Homo sapiens (Human).

Function: Important modulator in the HLA class II restricted antigen presentation pathway by interaction with the HLA-DM molecule in B-cells. Modifies peptide exchange activity of HLA-DM.

Subcellular location: Endosome membrane; Single-pass type I membrane protein. Lysosome membrane; Single-pass type I membrane protein. Note=Complexes with HLA-DM molecule during intracellular transport and in endosomal/lysosomal compartments. Heterotetramerization is necessary to exit the ER.

Transmembrane domains:

  1. 218-240, 23 AA, Helical. {ECO:0000255}.

Sequence: 250 AA

10 20 30 40 50 60 MALRAGLVLG FHTLMTLLSP QEAGATKADH MGSYGPAFYQ SYGASGQFTH EFDEEQLFSV 70 80 90 100 110 120 DLKKSEAVWR LPEFGDFARF DPQGGLAGIA AIKAHLDILV ERSNRSRAIN VPPRVTVLPK 130 140 150 160 170 180 SRVELGQPNI LICIVDNIFP PVINITWLRN GQTVTEGVAQ TSFYSQPDHL FRKFHYLPFV 190 200 210 220 230 240 PSAEDVYDCQ VEHWGLDAPL LRHWELQVPI PPPDAMETLV CALGLAIGLV GFLVGTVLII MGTYVSSVPR

CATM prediction

The sequence of DOA_HUMAN returned 3 potential models

The positions at the dimer's interface are highlighted in yellow. The position at the crossing point is highlighted in orange.

# Sequence and interface d θ Z' ω' Score
       220       230       240 
+    |    +    |    +    |   		 (Å) (°) (Å) (°)  
Model 1 AMETLVCALGLAIGLVGFLVGTVLIIMGT 6.6 +54.2° 3.3 79.8 -26.7
Model 2 AMETLVCALGLAIGLVGFLVGTVLIIMGT 7.4 -45.9° 3.6 36.8 -22.9
Model 3 AMETLVCALGLAIGLVGFLVGTVLIIMGT 7.0 -46.7° 1.3 45.0 -14.6

Click on the model number to visualize its details below.

MODEL 1 DETAILS

Precited structure:


Click on the image to enlarge

Download model 1 structure: PDB, PyMOL session

List of hydrogen bonds:

Donor Acceptor Distance
B, 225, LEU, HA A, 224, GLY, O 3.04Å
B, 228, GLY, HA1 A, 224, GLY, O 3.06Å
B, 228, GLY, HA2 A, 227, ILE, O 3.40Å
A, 225, LEU, HA B, 224, GLY, O 3.04Å
A, 228, GLY, HA1 B, 224, GLY, O 3.06Å
A, 228, GLY, HA2 B, 227, ILE, O 3.40Å