T-cell surface glycoprotein CD5

UniProt data

UniProt name: CD5_HUMAN (P06127)

Gene name: CD5; Synonyms=LEU1

Organism: Homo sapiens (Human).

Function: May act as a receptor in regulating T-cell proliferation.

Subcellular location: Cell membrane; Single-pass type I membrane protein.

Transmembrane domains:

  1. 373-402, 30 AA, Helical. {ECO:0000255}.

Sequence: 495 AA

10 20 30 40 50 60 MPMGSLQPLA TLYLLGMLVA SCLGRLSWYD PDFQARLTRS NSKCQGQLEV YLKDGWHMVC 70 80 90 100 110 120 SQSWGRSSKQ WEDPSQASKV CQRLNCGVPL SLGPFLVTYT PQSSIICYGQ LGSFSNCSHS 130 140 150 160 170 180 RNDMCHSLGL TCLEPQKTTP PTTRPPPTTT PEPTAPPRLQ LVAQSGGQHC AGVVEFYSGS 190 200 210 220 230 240 LGGTISYEAQ DKTQDLENFL CNNLQCGSFL KHLPETEAGR AQDPGEPREH QPLPIQWKIQ 250 260 270 280 290 300 NSSCTSLEHC FRKIKPQKSG RVLALLCSGF QPKVQSRLVG GSSICEGTVE VRQGAQWAAL 310 320 330 340 350 360 CDSSSARSSL RWEEVCREQQ CGSVNSYRVL DAGDPTSRGL FCPHQKLSQC HELWERNSYC 370 380 390 400 410 420 KKVFVTCQDP NPAGLAAGTV ASIILALVLL VVLLVVCGPL AYKKLVKKFR QKKQRQWIGP 430 440 450 460 470 480 TGMNQNMSFH RNHTATVRSH AENPTASHVD NEYSQPPRNS HLSAYPALEG ALHRSSMQPD 490 NSSDSDYDLH GAQRL

CATM prediction

The sequence of CD5_HUMAN returned 6 potential models

The positions at the dimer's interface are highlighted in yellow. The position at the crossing point is highlighted in orange.

# Sequence and interface d θ Z' ω' Score
  370       380       390       400   
|    +    |    +    |    +    |    +		 (Å) (°) (Å) (°)  
Model 1 ANAAGLAAGTVASIILALVLLVVLLVVCGALAYKKL 7.4 -23.0° 1.6 49.0 -14.8
Model 2 ANAAGLAAGTVASIILALVLLVVLLVVCGALAYKKL 6.8 -45.1° 5.6 44.9 -13.1
Model 3 ANAAGLAAGTVASIILALVLLVVLLVVCGALAYKKL 6.8 -32.0° 2.2 53.0 -11.6
Model 4 ANAAGLAAGTVASIILALVLLVVLLVVCGALAYKKL 7.4 -39.2° 2.7 44.0 -9.4
Model 5 ANAAGLAAGTVASIILALVLLVVLLVVCGALAYKKL 6.8 -55.0° 1.5 45.0 -0.9
Model 6 ANAAGLAAGTVASIILALVLLVVLLVVCGALAYKKL 6.8 -55.1° 1.5 44.9 -0.4
Prolines* PNPAGLAAGTVASIILALVLLVVLLVVCGPLAYKKL          

* Note: this sequence contains Pro residues. CATM substituted them with Ala during the modeling. The positions are marked.

Click on the model number to visualize its details below.

MODEL 1 DETAILS

Precited structure:


Click on the image to enlarge

Download model 1 structure: PDB, PyMOL session

List of hydrogen bonds:

Donor Acceptor Distance
B, 375, LEU, HA A, 374, GLY, O 3.45Å
A, 375, LEU, HA B, 374, GLY, O 3.45Å