Serine protease hepsin

UniProt data

UniProt name: HEPS_HUMAN (P05981)

Gene name: HPN; Synonyms=TMPRSS1

Organism: Homo sapiens (Human).

Function: Serine protease that cleaves extracellular substrates, and contributes to the proteolytic processing of growth factors, such as HGF and MST1/HGFL (PubMed:21875933, PubMed:15839837). Plays a role in cell growth and maintenance of cell morphology (PubMed:8346233, PubMed:21875933). Plays a role in the proteolytic processing of ACE2 (PubMed:24227843). Mediates the proteolytic cleavage of urinary UMOD that is required for UMOD polymerization (PubMed:26673890). {ECO:0000269|PubMed:15839837, ECO:0000269|PubMed:21875933, ECO:0000269|PubMed:24227843, ECO:0000269|PubMed:26673890, ECO:0000269|PubMed:8346233}.

Subcellular location: Cell membrane {ECO:0000269|PubMed:1885621}; Single-pass type II membrane protein {ECO:0000269|PubMed:1885621}. Apical cell membrane {ECO:0000269|PubMed:26673890}; Single-pass type II membrane protein {ECO:0000305}.

Transmembrane domains:

  1. 24-44, 21 AA, Helical; Signal-anchor for type II membrane protein. {ECO:0000255}.

Sequence: 417 AA

10 20 30 40 50 60 MAQKEGGRTV PCCSRPKVAA LTAGTLLLLT AIGAASWAIV AVLLRSDQEP LYPVQVSSAD 70 80 90 100 110 120 ARLMVFDKTE GTWRLLCSSR SNARVAGLSC EEMGFLRALT HSELDVRTAG ANGTSGFFCV 130 140 150 160 170 180 DEGRLPHTQR LLEVISVCDC PRGRFLAAIC QDCGRRKLPV DRIVGGRDTS LGRWPWQVSL 190 200 210 220 230 240 RYDGAHLCGG SLLSGDWVLT AAHCFPERNR VLSRWRVFAG AVAQASPHGL QLGVQAVVYH 250 260 270 280 290 300 GGYLPFRDPN SEENSNDIAL VHLSSPLPLT EYIQPVCLPA AGQALVDGKI CTVTGWGNTQ 310 320 330 340 350 360 YYGQQAGVLQ EARVPIISND VCNGADFYGN QIKPKMFCAG YPEGGIDACQ GDSGGPFVCE 370 380 390 400 410 DSISRTPRWR LCGIVSWGTG CALAQKPGVY TKVSDFREWI FQAIKTHSEA SGMVTQL

CATM prediction

The sequence of HEPS_HUMAN returned 1 potential models

The positions at the dimer's interface are highlighted in yellow. The position at the crossing point is highlighted in orange.

# Sequence and interface d θ Z' ω' Score
           30        40      
    +    |    +    |    +  		 (Å) (°) (Å) (°)  
Model 1 LTAGTLLLLTAIGAASWAIVAVLLRSD 6.8 -55.0° 1.5 45.6 -2.3

Click on the model number to visualize its details below.

MODEL 1 DETAILS

Precited structure:


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Download model 1 structure: PDB, PyMOL session

List of hydrogen bonds:

Donor Acceptor Distance
B, 30, THR, HA A, 29, LEU, O 3.38Å
B, 33, GLY, HA1 A, 30, THR, O 2.80Å
B, 34, ALA, HA A, 33, GLY, O 3.32Å
A, 30, THR, HA B, 29, LEU, O 3.38Å
A, 33, GLY, HA1 B, 30, THR, O 2.80Å
A, 34, ALA, HA B, 33, GLY, O 3.32Å