Integrin beta-1

UniProt data

UniProt name: ITB1_HUMAN (P05556)

Gene name: ITGB1; Synonyms=FNRB, MDF2, MSK12

Organism: Homo sapiens (Human).

Function: (Microbial infection) Integrin ITGA2:ITGB1 acts as a receptor for human echoviruses 1 and 8 (PubMed:8411387). Acts as a receptor for cytomegalovirus/HHV-5 (PubMed:20660204). Acts as a receptor for Epstein-Barr virus/HHV-4 (PubMed:17945327). Integrin ITGA5:ITGB1 acts as a receptor for human parvovirus B19 (PubMed:12907437). Integrin ITGA2:ITGB1 acts as a receptor for human rotavirus (PubMed:12941907). Acts as a receptor for mammalian reovirus (PubMed:16501085). In case of HIV-1 infection, integrin ITGA5:ITGB1 binding to extracellular viral Tat protein seems to enhance angiogenesis in Kaposi's sarcoma lesions (PubMed:10397733). {ECO:0000269|PubMed:10397733, ECO:0000269|PubMed:12907437, ECO:0000269|PubMed:12941907, ECO:0000269|PubMed:16501085, ECO:0000269|PubMed:17945327, ECO:0000269|PubMed:20660204, ECO:0000269|PubMed:8411387}.

Subcellular location: Isoform 5: Cell membrane, sarcolemma {ECO:0000250}. Cell junction {ECO:0000250}. Note=In cardiac muscle, isoform 5 is found in costameres and intercalated disks. {ECO:0000250}.

Transmembrane domains:

  1. 729-751, 23 AA, Helical. {ECO:0000255}.

Sequence: 798 AA

10 20 30 40 50 60 MNLQPIFWIG LISSVCCVFA QTDENRCLKA NAKSCGECIQ AGPNCGWCTN STFLQEGMPT 70 80 90 100 110 120 SARCDDLEAL KKKGCPPDDI ENPRGSKDIK KNKNVTNRSK GTAEKLKPED ITQIQPQQLV 130 140 150 160 170 180 LRLRSGEPQT FTLKFKRAED YPIDLYYLMD LSYSMKDDLE NVKSLGTDLM NEMRRITSDF 190 200 210 220 230 240 RIGFGSFVEK TVMPYISTTP AKLRNPCTSE QNCTSPFSYK NVLSLTNKGE VFNELVGKQR 250 260 270 280 290 300 ISGNLDSPEG GFDAIMQVAV CGSLIGWRNV TRLLVFSTDA GFHFAGDGKL GGIVLPNDGQ 310 320 330 340 350 360 CHLENNMYTM SHYYDYPSIA HLVQKLSENN IQTIFAVTEE FQPVYKELKN LIPKSAVGTL 370 380 390 400 410 420 SANSSNVIQL IIDAYNSLSS EVILENGKLS EGVTISYKSY CKNGVNGTGE NGRKCSNISI 430 440 450 460 470 480 GDEVQFEISI TSNKCPKKDS DSFKIRPLGF TEEVEVILQY ICECECQSEG IPESPKCHEG 490 500 510 520 530 540 NGTFECGACR CNEGRVGRHC ECSTDEVNSE DMDAYCRKEN SSEICSNNGE CVCGQCVCRK 550 560 570 580 590 600 RDNTNEIYSG KFCECDNFNC DRSNGLICGG NGVCKCRVCE CNPNYTGSAC DCSLDTSTCE 610 620 630 640 650 660 ASNGQICNGR GICECGVCKC TDPKFQGQTC EMCQTCLGVC AEHKECVQCR AFNKGEKKDT 670 680 690 700 710 720 CTQECSYFNI TKVESRDKLP QPVQPDPVSH CKEKDVDDCW FYFTYSVNGN NEVMVHVVEN 730 740 750 760 770 780 PECPTGPDII PIVAGVVAGI VLIGLALLLI WKLLMIIHDR REFAKFEKEK MNAKWDTGEN 790 PIYKSAVTTV VNPKYEGK

CATM prediction

The sequence of ITB1_HUMAN returned 1 potential models

The positions at the dimer's interface are highlighted in yellow. The position at the crossing point is highlighted in orange.

# Sequence and interface d θ Z' ω' Score
      730       740       750  
    |    +    |    +    |    		 (Å) (°) (Å) (°)  
Model 1 GADIIAIVAGVVAGIVLIGLALLLIWKLL 7.1 -49.0° 1.8 45.3 -31.5
Prolines* GPDIIPIVAGVVAGIVLIGLALLLIWKLL          

* Note: this sequence contains Pro residues. CATM substituted them with Ala during the modeling. The positions are marked.

Click on the model number to visualize its details below.

MODEL 1 DETAILS

Precited structure:


Click on the image to enlarge

Download model 1 structure: PDB, PyMOL session

List of hydrogen bonds:

Donor Acceptor Distance
B, 732, ILE, HA A, 731, ALA, O 3.43Å
B, 735, GLY, HA1 A, 732, ILE, O 2.90Å
B, 736, VAL, HA A, 735, GLY, O 2.90Å
A, 732, ILE, HA B, 731, ALA, O 3.43Å
A, 735, GLY, HA1 B, 732, ILE, O 2.90Å
A, 736, VAL, HA B, 735, GLY, O 2.90Å