UniProt data
UniProt name: PPB1_HUMAN (P05187)
Gene name: ALPP; Synonyms=PLAP
Organism: Homo sapiens (Human).
Function:
Subcellular location: Cell membrane; Lipid-anchor, GPI-anchor.
Transmembrane domains:
- 513-529, 17 AA, Helical.
Sequence: 535 AA
10 20 30 40 50 60
MLGPCMLLLL LLLGLRLQLS LGIIPVEEEN PDFWNREAAE ALGAAKKLQP AQTAAKNLII
70 80 90 100 110 120
FLGDGMGVST VTAARILKGQ KKDKLGPEIP LAMDRFPYVA LSKTYNVDKH VPDSGATATA
130 140 150 160 170 180
YLCGVKGNFQ TIGLSAAARF NQCNTTRGNE VISVMNRAKK AGKSVGVVTT TRVQHASPAG
190 200 210 220 230 240
TYAHTVNRNW YSDADVPASA RQEGCQDIAT QLISNMDIDV ILGGGRKYMF RMGTPDPEYP
250 260 270 280 290 300
DDYSQGGTRL DGKNLVQEWL AKRQGARYVW NRTELMQASL DPSVTHLMGL FEPGDMKYEI
310 320 330 340 350 360
HRDSTLDPSL MEMTEAALRL LSRNPRGFFL FVEGGRIDHG HHESRAYRAL TETIMFDDAI
370 380 390 400 410 420
ERAGQLTSEE DTLSLVTADH SHVFSFGGYP LRGSSIFGLA PGKARDRKAY TVLLYGNGPG
430 440 450 460 470 480
YVLKDGARPD VTESESGSPE YRQQSAVPLD EETHAGEDVA VFARGPQAHL VHGVQEQTFI
490 500 510 520 530
AHVMAFAACL EPYTACDLAP PAGTTDAAHP GRSVVPALLP LLAGTLLLLE TATAP
CATM prediction
The sequence of PPB1_HUMAN returned 1 potential models
The positions at the dimer's interface are highlighted in yellow. The position at the crossing point is highlighted in orange.
| # | Sequence and interface | d | θ | Z' | ω' | Score |
|---|---|---|---|---|---|---|
| 510 520 530 | + | + | |
(Å) | (°) | (Å) | (°) | ||
| Model 1 | AGRSVVAALLALLAGTLLLLETA | 7.0 | -36.1° | 1.5 | 36.3 | -2.5 |
| Prolines* | PGRSVVPALLPLLAGTLLLLETA |
* Note: this sequence contains Pro residues. CATM substituted them with Ala during the modeling. The positions are marked.
Click on the model number to visualize its details below.
MODEL 1 DETAILS
Precited structure:
Click on the image to enlarge
Download model 1 structure: PDB, PyMOL session
List of hydrogen bonds:
| Donor | Acceptor | Distance |
|---|---|---|
| B, 513, SER, HA | A, 513, SER, OG | 3.25Å |
| B, 517, ALA, HA | A, 516, ALA, O | 3.36Å |
| A, 513, SER, HA | B, 513, SER, OG | 3.25Å |
| A, 517, ALA, HA | B, 516, ALA, O | 3.36Å |