Integrin beta-2

UniProt data

UniProt name: ITB2_HUMAN (P05107)

Gene name: ITGB2; Synonyms=CD18, MFI7

Organism: Homo sapiens (Human).

Function: Integrin alpha-L/beta-2 is a receptor for ICAM1, ICAM2, ICAM3 and ICAM4. Integrins alpha-M/beta-2 and alpha-X/beta-2 are receptors for the iC3b fragment of the third complement component and for fibrinogen. Integrin alpha-X/beta-2 recognizes the sequence G-P-R in fibrinogen alpha-chain. Integrin alpha-M/beta-2 recognizes P1 and P2 peptides of fibrinogen gamma chain. Integrin alpha-M/beta-2 is also a receptor for factor X. Integrin alpha- D/beta-2 is a receptor for ICAM3 and VCAM1. Contributes to natural killer cell cytotoxicity (PubMed:15356110). Involved in leukocyte adhesion and transmigration of leukocytes including T-cells and neutrophils (PubMed:11812992). Triggers neutrophil transmigration during lung injury through PTK2B/PYK2-mediated activation (PubMed:18587400). Integrin alpha-L/beta-2 in assosiation with ICAM3, contributes to apoptotic neutrophil phagocytosis by macrophages (PubMed:23775590). {ECO:0000269|PubMed:11812992, ECO:0000269|PubMed:15356110, ECO:0000269|PubMed:18587400, ECO:0000269|PubMed:23775590}.

Subcellular location: Membrane; Single-pass type I membrane protein.

Transmembrane domains:

  1. 701-723, 23 AA, Helical. {ECO:0000255}.

Sequence: 769 AA

10 20 30 40 50 60 MLGLRPPLLA LVGLLSLGCV LSQECTKFKV SSCRECIESG PGCTWCQKLN FTGPGDPDSI 70 80 90 100 110 120 RCDTRPQLLM RGCAADDIMD PTSLAETQED HNGGQKQLSP QKVTLYLRPG QAAAFNVTFR 130 140 150 160 170 180 RAKGYPIDLY YLMDLSYSML DDLRNVKKLG GDLLRALNEI TESGRIGFGS FVDKTVLPFV 190 200 210 220 230 240 NTHPDKLRNP CPNKEKECQP PFAFRHVLKL TNNSNQFQTE VGKQLISGNL DAPEGGLDAM 250 260 270 280 290 300 MQVAACPEEI GWRNVTRLLV FATDDGFHFA GDGKLGAILT PNDGRCHLED NLYKRSNEFD 310 320 330 340 350 360 YPSVGQLAHK LAENNIQPIF AVTSRMVKTY EKLTEIIPKS AVGELSEDSS NVVQLIKNAY 370 380 390 400 410 420 NKLSSRVFLD HNALPDTLKV TYDSFCSNGV THRNQPRGDC DGVQINVPIT FQVKVTATEC 430 440 450 460 470 480 IQEQSFVIRA LGFTDIVTVQ VLPQCECRCR DQSRDRSLCH GKGFLECGIC RCDTGYIGKN 490 500 510 520 530 540 CECQTQGRSS QELEGSCRKD NNSIICSGLG DCVCGQCLCH TSDVPGKLIY GQYCECDTIN 550 560 570 580 590 600 CERYNGQVCG GPGRGLCFCG KCRCHPGFEG SACQCERTTE GCLNPRRVEC SGRGRCRCNV 610 620 630 640 650 660 CECHSGYQLP LCQECPGCPS PCGKYISCAE CLKFEKGPFG KNCSAACPGL QLSNNPVKGR 670 680 690 700 710 720 TCKERDSEGC WVAYTLEQQD GMDRYLIYVD ESRECVAGPN IAAIVGGTVA GIVLIGILLL 730 740 750 760 VIWKALIHLS DLREYRRFEK EKLKSQWNND NPLFKSATTT VMNPKFAES

CATM prediction

The sequence of ITB2_HUMAN returned 4 potential models

The positions at the dimer's interface are highlighted in yellow. The position at the crossing point is highlighted in orange.

# Sequence and interface d θ Z' ω' Score
    700       710       720    
  |    +    |    +    |    + 		 (Å) (°) (Å) (°)  
Model 1 GANIAAIVGGTVAGIVLIGILLLVIWKAL 6.7 -49.0° 1.8 44.9 -36.6
Model 2 GANIAAIVGGTVAGIVLIGILLLVIWKAL 6.7 -48.0° 1.0 37.0 -16.8
Model 3 GANIAAIVGGTVAGIVLIGILLLVIWKAL 6.8 -54.7° 4.2 38.1 -9.5
Model 4 GANIAAIVGGTVAGIVLIGILLLVIWKAL 7.3 -29.0° 2.5 37.0 -9.4
Prolines* GPNIAAIVGGTVAGIVLIGILLLVIWKAL          

* Note: this sequence contains Pro residues. CATM substituted them with Ala during the modeling. The positions are marked.

Click on the model number to visualize its details below.

MODEL 1 DETAILS

Precited structure:


Click on the image to enlarge

Download model 1 structure: PDB, PyMOL session

List of hydrogen bonds:

Donor Acceptor Distance
B, 704, ILE, HA A, 703, ALA, O 3.17Å
B, 707, GLY, HA1 A, 704, ILE, O 2.66Å
B, 708, THR, HA A, 707, GLY, O 2.79Å
B, 708, THR, HG1 A, 707, GLY, O 2.40Å
A, 704, ILE, HA B, 703, ALA, O 3.17Å
A, 707, GLY, HA1 B, 704, ILE, O 2.66Å
A, 708, THR, HA B, 707, GLY, O 2.79Å
A, 708, THR, HG1 B, 707, GLY, O 2.40Å