Glycophorin-C

UniProt data

UniProt name: GLPC_HUMAN (P04921)

Gene name: GYPC; Synonyms=GLPC, GPC

Organism: Homo sapiens (Human).

Function: This protein is a minor sialoglycoprotein in human erythrocyte membranes. The blood group Gerbich antigens and receptors for Plasmodium falciparum merozoites are most likely located within the extracellular domain. Glycophorin-C plays an important role in regulating the stability of red cells.

Subcellular location: Cell membrane; Single-pass type III membrane protein. Note=Linked to the membrane via band 4.1.

Transmembrane domains:

  1. 58-81, 24 AA, Helical; Signal-anchor for type III membrane protein.

Sequence: 128 AA

10 20 30 40 50 60 MWSTRSPNST AWPLSLEPDP GMASASTTMH TTTIAEPDPG MSGWPDGRME TSTPTIMDIV 70 80 90 100 110 120 VIAGVIAAVA IVLVSLLFVM LRYMYRHKGT YHTNEAKGTE FAESADAALQ GDPALQDAGD SSRKEYFI

CATM prediction

The sequence of GLPC_HUMAN returned 1 potential models

The positions at the dimer's interface are highlighted in yellow. The position at the crossing point is highlighted in orange.

# Sequence and interface d θ Z' ω' Score
       60        70        80   
+    |    +    |    +    |    		 (Å) (°) (Å) (°)  
Model 1 TIMDIVVIAGVIAAVAIVLVSLLFVMLRYM 7.4 -48.0° 0.5 46.9 -3.0

Click on the model number to visualize its details below.

MODEL 1 DETAILS

Precited structure:


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Download model 1 structure: PDB, PyMOL session

List of hydrogen bonds:

Donor Acceptor Distance
B, 64, GLY, HA1 A, 61, VAL, O 3.48Å
B, 65, VAL, HA A, 64, GLY, O 3.41Å
A, 64, GLY, HA1 B, 61, VAL, O 3.48Å
A, 65, VAL, HA B, 64, GLY, O 3.41Å