Receptor tyrosine-protein kinase erbB-2

UniProt data

UniProt name: ERBB2_HUMAN (P04626)

Gene name: ERBB2; Synonyms=HER2, MLN19, NEU, NGL

Organism: Homo sapiens (Human).

Function: In the nucleus is involved in transcriptional regulation. Associates with the 5'-TCAAATTC-3' sequence in the PTGS2/COX-2 promoter and activates its transcription. Implicated in transcriptional activation of CDKN1A; the function involves STAT3 and SRC. Involved in the transcription of rRNA genes by RNA Pol I and enhances protein synthesis and cell growth. {ECO:0000269|PubMed:10358079, ECO:0000269|PubMed:15380516, ECO:0000269|PubMed:21555369}.

Subcellular location: Isoform 3: Cytoplasm. Nucleus.

Transmembrane domains:

  1. 653-675, 23 AA, Helical. {ECO:0000255}.

Sequence: 1255 AA

10 20 30 40 50 60 MELAALCRWG LLLALLPPGA ASTQVCTGTD MKLRLPASPE THLDMLRHLY QGCQVVQGNL 70 80 90 100 110 120 ELTYLPTNAS LSFLQDIQEV QGYVLIAHNQ VRQVPLQRLR IVRGTQLFED NYALAVLDNG 130 140 150 160 170 180 DPLNNTTPVT GASPGGLREL QLRSLTEILK GGVLIQRNPQ LCYQDTILWK DIFHKNNQLA 190 200 210 220 230 240 LTLIDTNRSR ACHPCSPMCK GSRCWGESSE DCQSLTRTVC AGGCARCKGP LPTDCCHEQC 250 260 270 280 290 300 AAGCTGPKHS DCLACLHFNH SGICELHCPA LVTYNTDTFE SMPNPEGRYT FGASCVTACP 310 320 330 340 350 360 YNYLSTDVGS CTLVCPLHNQ EVTAEDGTQR CEKCSKPCAR VCYGLGMEHL REVRAVTSAN 370 380 390 400 410 420 IQEFAGCKKI FGSLAFLPES FDGDPASNTA PLQPEQLQVF ETLEEITGYL YISAWPDSLP 430 440 450 460 470 480 DLSVFQNLQV IRGRILHNGA YSLTLQGLGI SWLGLRSLRE LGSGLALIHH NTHLCFVHTV 490 500 510 520 530 540 PWDQLFRNPH QALLHTANRP EDECVGEGLA CHQLCARGHC WGPGPTQCVN CSQFLRGQEC 550 560 570 580 590 600 VEECRVLQGL PREYVNARHC LPCHPECQPQ NGSVTCFGPE ADQCVACAHY KDPPFCVARC 610 620 630 640 650 660 PSGVKPDLSY MPIWKFPDEE GACQPCPINC THSCVDLDDK GCPAEQRASP LTSIISAVVG 670 680 690 700 710 720 ILLVVVLGVV FGILIKRRQQ KIRKYTMRRL LQETELVEPL TPSGAMPNQA QMRILKETEL 730 740 750 760 770 780 RKVKVLGSGA FGTVYKGIWI PDGENVKIPV AIKVLRENTS PKANKEILDE AYVMAGVGSP 790 800 810 820 830 840 YVSRLLGICL TSTVQLVTQL MPYGCLLDHV RENRGRLGSQ DLLNWCMQIA KGMSYLEDVR 850 860 870 880 890 900 LVHRDLAARN VLVKSPNHVK ITDFGLARLL DIDETEYHAD GGKVPIKWMA LESILRRRFT 910 920 930 940 950 960 HQSDVWSYGV TVWELMTFGA KPYDGIPARE IPDLLEKGER LPQPPICTID VYMIMVKCWM 970 980 990 1000 1010 1020 IDSECRPRFR ELVSEFSRMA RDPQRFVVIQ NEDLGPASPL DSTFYRSLLE DDDMGDLVDA 1030 1040 1050 1060 1070 1080 EEYLVPQQGF FCPDPAPGAG GMVHHRHRSS STRSGGGDLT LGLEPSEEEA PRSPLAPSEG 1090 1100 1110 1120 1130 1140 AGSDVFDGDL GMGAAKGLQS LPTHDPSPLQ RYSEDPTVPL PSETDGYVAP LTCSPQPEYV 1150 1160 1170 1180 1190 1200 NQPDVRPQPP SPREGPLPAA RPAGATLERP KTLSPGKNGV VKDVFAFGGA VENPEYLTPQ 1210 1220 1230 1240 1250 GGAAPQPHPP PAFSPAFDNL YYWDQDPPER GAPPSTFKGT PTAENPEYLG LDVPV

CATM prediction

The sequence of ERBB2_HUMAN returned 3 potential models

The positions at the dimer's interface are highlighted in yellow. The position at the crossing point is highlighted in orange.

# Sequence and interface d θ Z' ω' Score
  650       660       670      
|    +    |    +    |    +   		 (Å) (°) (Å) (°)  
Model 1 ALTSIISAVVGILLVVVLGVVFGILIKRR 6.6 -50.9° 4.8 57.4 -38.1
Model 2 ALTSIISAVVGILLVVVLGVVFGILIKRR 7.0 -54.8° 2.4 48.0 -23.1
Model 3 ALTSIISAVVGILLVVVLGVVFGILIKRR 7.4 -45.0° 4.0 38.8 -15.6
Prolines* PLTSIISAVVGILLVVVLGVVFGILIKRR          

* Note: this sequence contains Pro residues. CATM substituted them with Ala during the modeling. The positions are marked.

Click on the model number to visualize its details below.

MODEL 1 DETAILS

Precited structure:


Click on the image to enlarge

Download model 1 structure: PDB, PyMOL session

List of hydrogen bonds:

Donor Acceptor Distance
B, 668, GLY, HA1 A, 665, VAL, O 3.00Å
B, 669, VAL, HA A, 668, GLY, O 2.46Å
B, 672, GLY, HA1 A, 669, VAL, O 3.17Å
A, 668, GLY, HA1 B, 665, VAL, O 3.00Å
A, 669, VAL, HA B, 668, GLY, O 2.46Å
A, 672, GLY, HA1 B, 669, VAL, O 3.17Å