HLA class II histocompatibility antigen, DRB1-1 beta chain

UniProt data

UniProt name: 2B11_HUMAN (P04229)

Gene name: HLA-DRB1

Organism: Homo sapiens (Human).

Function: (Microbial infection) Acts as a receptor for Epstein- Barr virus on lymphocytes. {ECO:0000269|PubMed:11864610, ECO:0000269|PubMed:9151859}.

Subcellular location: Cell membrane {ECO:0000269|PubMed:18305173}; Single-pass type I membrane protein {ECO:0000269|PubMed:18305173}. Endoplasmic reticulum membrane {ECO:0000269|PubMed:18305173}; Single-pass type I membrane protein {ECO:0000269|PubMed:18305173}. Golgi apparatus, trans-Golgi network membrane {ECO:0000269|PubMed:18305173}; Single-pass type I membrane protein {ECO:0000269|PubMed:18305173}. Endosome membrane {ECO:0000269|PubMed:18305173}; Single-pass type I membrane protein {ECO:0000269|PubMed:18305173}. Lysosome membrane {ECO:0000269|PubMed:18305173}; Single-pass type I membrane protein {ECO:0000269|PubMed:18305173}. Late endosome membrane {ECO:0000269|PubMed:18305173}; Single-pass type I membrane protein {ECO:0000269|PubMed:18305173}. Note=The MHC class II complex transits through a number of intracellular compartments in the endocytic pathway until it reaches the cell membrane for antigen presentation.

Transmembrane domains:

  1. 228-250, 23 AA, Helical. {ECO:0000255}.

Sequence: 266 AA

10 20 30 40 50 60 MVCLKLPGGS CMTALTVTLM VLSSPLALAG DTRPRFLWQL KFECHFFNGT ERVRLLERCI 70 80 90 100 110 120 YNQEESVRFD SDVGEYRAVT ELGRPDAEYW NSQKDLLEQR RAAVDTYCRH NYGVGESFTV 130 140 150 160 170 180 QRRVEPKVTV YPSKTQPLQH HNLLVCSVSG FYPGSIEVRW FRNGQEEKAG VVSTGLIQNG 190 200 210 220 230 240 DWTFQTLVML ETVPRSGEVY TCQVEHPSVT SPLTVEWRAR SESAQSKMLS GVGGFVLGLL 250 260 FLGAGLFIYF RNQKGHSGLQ PTGFLS

CATM prediction

The sequence of 2B11_HUMAN returned 4 potential models

The positions at the dimer's interface are highlighted in yellow. The position at the crossing point is highlighted in orange.

# Sequence and interface d θ Z' ω' Score
       230       240       250 
+    |    +    |    +    |   		 (Å) (°) (Å) (°)  
Model 1 QSKMLSGVGGFVLGLLFLGAGLFIYFRNQ 7.2 -20.0° 0.0 50.0 -31.7
Model 2 QSKMLSGVGGFVLGLLFLGAGLFIYFRNQ 7.4 -42.0° 2.8 50.0 -20.3
Model 3 QSKMLSGVGGFVLGLLFLGAGLFIYFRNQ 7.2 -51.0° 4.3 40.0 -9.7
Model 4 QSKMLSGVGGFVLGLLFLGAGLFIYFRNQ 7.2 -32.0° 3.5 37.8 -7.0

Click on the model number to visualize its details below.

MODEL 1 DETAILS

Precited structure:


Click on the image to enlarge

Download model 1 structure: PDB, PyMOL session

List of hydrogen bonds:

Donor Acceptor Distance
B, 231, GLY, HA2 A, 230, SER, O 3.05Å
A, 231, GLY, HA2 B, 230, SER, O 3.05Å
A, 245, GLY, HA1 B, 249, TYR, OH 3.41Å
A, 246, LEU, HA B, 249, TYR, OH 2.80Å