HLA class I histocompatibility antigen, Cw-3 alpha chain

UniProt data

UniProt name: 1C03_HUMAN (P04222)

Gene name: HLA-C; Synonyms=HLAC

Organism: Homo sapiens (Human).

Function: Involved in the presentation of foreign antigens to the immune system.

Subcellular location: Membrane; Single-pass type I membrane protein.

Transmembrane domains:

  1. 309-333, 25 AA, Helical. {ECO:0000255}.

Sequence: 366 AA

10 20 30 40 50 60 MRVMAPRTLI LLLSGALALT ETWAGSHSMR YFYTAVSRPG RGEPHFIAVG YVDDTQFVRF 70 80 90 100 110 120 DSDAASPRGE PRAPWVEQEG PEYWDRETQK YKRQAQTDRV SLRNLRGYYN QSEAGSHIIQ 130 140 150 160 170 180 RMYGCDVGPD GRLLRGYDQY AYDGKDYIAL NEDLRSWTAA DTAAQITQRK WEAAREAEQL 190 200 210 220 230 240 RAYLEGLCVE WLRRYLKNGK ETLQRAEHPK THVTHHPVSD HEATLRCWAL GFYPAEITLT 250 260 270 280 290 300 WQWDGEDQTQ DTELVETRPA GDGTFQKWAA VVVPSGEEQR YTCHVQHEGL PEPLTLRWEP 310 320 330 340 350 360 SSQPTIPIVG IVAGLAVLAV LAVLGAVVAV VMCRRKSSGG KGGSCSQAAS SNSAQGSDES LIACKA

CATM prediction

The sequence of 1C03_HUMAN returned 2 potential models

The positions at the dimer's interface are highlighted in yellow. The position at the crossing point is highlighted in orange.

# Sequence and interface d θ Z' ω' Score
      310       320       330    
    |    +    |    +    |    + 		 (Å) (°) (Å) (°)  
Model 1 IAIVGIVAGLAVLAVLAVLGAVVAVVMCRRK 6.8 -55.1° 0.9 50.3 -19.8
Model 2 IAIVGIVAGLAVLAVLAVLGAVVAVVMCRRK 7.3 -51.0° 2.4 45.0 -5.9
Prolines* IPIVGIVAGLAVLAVLAVLGAVVAVVMCRRK          

* Note: this sequence contains Pro residues. CATM substituted them with Ala during the modeling. The positions are marked.

Click on the model number to visualize its details below.

MODEL 1 DETAILS

Precited structure:


Click on the image to enlarge

Download model 1 structure: PDB, PyMOL session

List of hydrogen bonds:

Donor Acceptor Distance
B, 322, ALA, HA A, 321, LEU, O 3.43Å
B, 325, GLY, HA1 A, 322, ALA, O 2.78Å
B, 326, ALA, HA A, 325, GLY, O 3.15Å
A, 322, ALA, HA B, 321, LEU, O 3.43Å
A, 325, GLY, HA1 B, 322, ALA, O 2.78Å
A, 326, ALA, HA B, 325, GLY, O 3.15Å