HLA class I histocompatibility antigen, B-27 alpha chain

UniProt data

UniProt name: 1B27_HUMAN (P03989)

Gene name: HLA-B; Synonyms=HLAB

Organism: Homo sapiens (Human).

Function: Involved in the presentation of foreign antigens to the immune system.

Subcellular location: Membrane; Single-pass type I membrane protein.

Transmembrane domains:

  1. 309-332, 24 AA, Helical. {ECO:0000255}.

Sequence: 362 AA

10 20 30 40 50 60 MRVTAPRTLL LLLWGAVALT ETWAGSHSMR YFHTSVSRPG RGEPRFITVG YVDDTLFVRF 70 80 90 100 110 120 DSDAASPREE PRAPWIEQEG PEYWDRETQI CKAKAQTDRE DLRTLLRYYN QSEAGSHTLQ 130 140 150 160 170 180 NMYGCDVGPD GRLLRGYHQD AYDGKDYIAL NEDLSSWTAA DTAAQITQRK WEAARVAEQL 190 200 210 220 230 240 RAYLEGECVE WLRRYLENGK ETLQRADPPK THVTHHPISD HEATLRCWAL GFYPAEITLT 250 260 270 280 290 300 WQRDGEDQTQ DTELVETRPA GDRTFQKWAA VVVPSGEEQR YTCHVQHEGL PKPLTLRWEP 310 320 330 340 350 360 SSQSTVPIVG IVAGLAVLAV VVIGAVVAAV MCRRKSSGGK GGSYSQAACS DSAQGSDVSL TA

CATM prediction

The sequence of 1B27_HUMAN returned 1 potential models

The positions at the dimer's interface are highlighted in yellow. The position at the crossing point is highlighted in orange.

# Sequence and interface d θ Z' ω' Score
      310       320       330   
    |    +    |    +    |    +		 (Å) (°) (Å) (°)  
Model 1 VAIVGIVAGLAVLAVVVIGAVVAAVMCRRK 7.0 -52.2° 0.6 48.1 -12.6
Prolines* VPIVGIVAGLAVLAVVVIGAVVAAVMCRRK          

* Note: this sequence contains Pro residues. CATM substituted them with Ala during the modeling. The positions are marked.

Click on the model number to visualize its details below.

MODEL 1 DETAILS

Precited structure:


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Download model 1 structure: PDB, PyMOL session

List of hydrogen bonds:

Donor Acceptor Distance
B, 324, GLY, HA1 A, 321, VAL, O 3.10Å
B, 325, ALA, HA A, 324, GLY, O 3.18Å
A, 324, GLY, HA1 B, 321, VAL, O 3.10Å
A, 325, ALA, HA B, 324, GLY, O 3.18Å