Transferrin receptor protein 1

UniProt data

UniProt name: TFR1_HUMAN (P02786)

Gene name: TFRC

Organism: Homo sapiens (Human).

Function: (Microbial infection) Acts as a receptor for new-world arenaviruses: Guanarito, Junin and Machupo virus. {ECO:0000269|PubMed:17287727, ECO:0000269|PubMed:18268337}.

Subcellular location: Transferrin receptor protein 1, serum form: Secreted {ECO:0000269|PubMed:17081065}.

Transmembrane domains:

  1. 68-88, 21 AA, Helical; Signal-anchor for type II membrane protein. {ECO:0000255}.

Sequence: 760 AA

10 20 30 40 50 60 MMDQARSAFS NLFGGEPLSY TRFSLARQVD GDNSHVEMKL AVDEEENADN NTKANVTKPK 70 80 90 100 110 120 RCSGSICYGT IAVIVFFLIG FMIGYLGYCK GVEPKTECER LAGTESPVRE EPGEDFPAAR 130 140 150 160 170 180 RLYWDDLKRK LSEKLDSTDF TGTIKLLNEN SYVPREAGSQ KDENLALYVE NQFREFKLSK 190 200 210 220 230 240 VWRDQHFVKI QVKDSAQNSV IIVDKNGRLV YLVENPGGYV AYSKAATVTG KLVHANFGTK 250 260 270 280 290 300 KDFEDLYTPV NGSIVIVRAG KITFAEKVAN AESLNAIGVL IYMDQTKFPI VNAELSFFGH 310 320 330 340 350 360 AHLGTGDPYT PGFPSFNHTQ FPPSRSSGLP NIPVQTISRA AAEKLFGNME GDCPSDWKTD 370 380 390 400 410 420 STCRMVTSES KNVKLTVSNV LKEIKILNIF GVIKGFVEPD HYVVVGAQRD AWGPGAAKSG 430 440 450 460 470 480 VGTALLLKLA QMFSDMVLKD GFQPSRSIIF ASWSAGDFGS VGATEWLEGY LSSLHLKAFT 490 500 510 520 530 540 YINLDKAVLG TSNFKVSASP LLYTLIEKTM QNVKHPVTGQ FLYQDSNWAS KVEKLTLDNA 550 560 570 580 590 600 AFPFLAYSGI PAVSFCFCED TDYPYLGTTM DTYKELIERI PELNKVARAA AEVAGQFVIK 610 620 630 640 650 660 LTHDVELNLD YERYNSQLLS FVRDLNQYRA DIKEMGLSLQ WLYSARGDFF RATSRLTTDF 670 680 690 700 710 720 GNAEKTDRFV MKKLNDRVMR VEYHFLSPYV SPKESPFRHV FWGSGSHTLP ALLENLKLRK 730 740 750 QNNGAFNETL FRNQLALATW TIQGAANALS GDVWDIDNEF

CATM prediction

The sequence of TFR1_HUMAN returned 3 potential models

The positions at the dimer's interface are highlighted in yellow. The position at the crossing point is highlighted in orange.

# Sequence and interface d θ Z' ω' Score
       70        80        90
+    |    +    |    +    | 		 (Å) (°) (Å) (°)  
Model 1 SICYGTIAVIVFFLIGFMIGYLGYCKG 7.2 -53.0° 2.0 44.8 -27.5
Model 2 SICYGTIAVIVFFLIGFMIGYLGYCKG 7.3 -54.1° 2.9 50.8 -11.1
Model 3 SICYGTIAVIVFFLIGFMIGYLGYCKG 6.7 +52.8° 2.7 88.0 -9.3

Click on the model number to visualize its details below.

MODEL 1 DETAILS

Precited structure:


Click on the image to enlarge

Download model 1 structure: PDB, PyMOL session

List of hydrogen bonds:

Donor Acceptor Distance
B, 80, GLY, HA1 A, 77, PHE, O 3.03Å
B, 81, PHE, HA A, 80, GLY, O 3.14Å
A, 80, GLY, HA1 B, 77, PHE, O 3.03Å
A, 81, PHE, HA B, 80, GLY, O 3.15Å