Glycophorin-A

UniProt data

UniProt name: GLPA_HUMAN (P02724)

Gene name: GYPA; Synonyms=GPA

Organism: Homo sapiens (Human).

Function: Glycophorin A is the major intrinsic membrane protein of the erythrocyte. The N-terminal glycosylated segment, which lies outside the erythrocyte membrane, has MN blood group receptors. Appears to be important for the function of SLC4A1 and is required for high activity of SLC4A1. May be involved in translocation of SLC4A1 to the plasma membrane. Is a receptor for influenza virus. Is a receptor for Plasmodium falciparum erythrocyte-binding antigen 175 (EBA-175); binding of EBA-175 is dependent on sialic acid residues of the O-linked glycans. Appears to be a receptor for Hepatitis A virus (HAV). {ECO:0000269|PubMed:10926825, ECO:0000269|PubMed:12813056, ECO:0000269|PubMed:14604989, ECO:0000269|PubMed:15331714, ECO:0000269|PubMed:19438409, ECO:0000269|PubMed:8009226}.

Subcellular location: Cell membrane {ECO:0000269|PubMed:11402026}; Single-pass type I membrane protein {ECO:0000269|PubMed:11402026}. Note=Appears to be colocalized with SLC4A1.

Transmembrane domains:

  1. 92-114, 23 AA, Helical.

Sequence: 150 AA

10 20 30 40 50 60 MYGKIIFVLL LSEIVSISAS STTGVAMHTS TSSSVTKSYI SSQTNDTHKR DTYAATPRAH 70 80 90 100 110 120 EVSEISVRTV YPPEEETGER VQLAHHFSEP EITLIIFGVM AGVIGTILLI SYGIRRLIKK 130 140 SPSDVKPLPS PDTDVPLSSV EIENPETSDQ

CATM prediction

The sequence of GLPA_HUMAN returned 3 potential models

The positions at the dimer's interface are highlighted in yellow. The position at the crossing point is highlighted in orange.

# Sequence and interface d θ Z' ω' Score
   90        100       110     
 |    +    |    +    |    +  		 (Å) (°) (Å) (°)  
Model 1 EAEITLIIFGVMAGVIGTILLISYGIRRL 6.7 -49.1° 4.5 48.8 -18.1
Model 2 EAEITLIIFGVMAGVIGTILLISYGIRRL 6.9 -51.1° 4.4 39.8 -12.1
Model 3 EAEITLIIFGVMAGVIGTILLISYGIRRL 7.0 -54.8° 1.5 44.6 -6.7
Prolines* EPEITLIIFGVMAGVIGTILLISYGIRRL          

* Note: this sequence contains Pro residues. CATM substituted them with Ala during the modeling. The positions are marked.

Click on the model number to visualize its details below.

MODEL 1 DETAILS

Precited structure:


Click on the image to enlarge

Download model 1 structure: PDB, PyMOL session

List of hydrogen bonds:

Donor Acceptor Distance
B, 98, GLY, HA1 A, 95, ILE, O 3.45Å
B, 99, VAL, HA A, 98, GLY, O 2.54Å
B, 102, GLY, HA1 A, 99, VAL, O 2.89Å
B, 103, VAL, HA A, 106, THR, OG1 2.93Å
A, 98, GLY, HA1 B, 95, ILE, O 3.45Å
A, 99, VAL, HA B, 98, GLY, O 2.54Å
A, 102, GLY, HA1 B, 99, VAL, O 2.89Å
A, 103, VAL, HA B, 106, THR, OG1 2.93Å