Polymeric immunoglobulin receptor

UniProt data

UniProt name: PIGR_HUMAN (P01833)

Gene name: PIGR

Organism: Homo sapiens (Human).

Function: This receptor binds polymeric IgA and IgM at the basolateral surface of epithelial cells. The complex is then transported across the cell to be secreted at the apical surface. During this process a cleavage occurs that separates the extracellular (known as the secretory component) from the transmembrane segment.

Subcellular location: Secretory component: Secreted.

Transmembrane domains:

  1. 639-661, 23 AA, Helical. {ECO:0000255}.

Sequence: 764 AA

10 20 30 40 50 60 MLLFVLTCLL AVFPAISTKS PIFGPEEVNS VEGNSVSITC YYPPTSVNRH TRKYWCRQGA 70 80 90 100 110 120 RGGCITLISS EGYVSSKYAG RANLTNFPEN GTFVVNIAQL SQDDSGRYKC GLGINSRGLS 130 140 150 160 170 180 FDVSLEVSQG PGLLNDTKVY TVDLGRTVTI NCPFKTENAQ KRKSLYKQIG LYPVLVIDSS 190 200 210 220 230 240 GYVNPNYTGR IRLDIQGTGQ LLFSVVINQL RLSDAGQYLC QAGDDSNSNK KNADLQVLKP 250 260 270 280 290 300 EPELVYEDLR GSVTFHCALG PEVANVAKFL CRQSSGENCD VVVNTLGKRA PAFEGRILLN 310 320 330 340 350 360 PQDKDGSFSV VITGLRKEDA GRYLCGAHSD GQLQEGSPIQ AWQLFVNEES TIPRSPTVVK 370 380 390 400 410 420 GVAGGSVAVL CPYNRKESKS IKYWCLWEGA QNGRCPLLVD SEGWVKAQYE GRLSLLEEPG 430 440 450 460 470 480 NGTFTVILNQ LTSRDAGFYW CLTNGDTLWR TTVEIKIIEG EPNLKVPGNV TAVLGETLKV 490 500 510 520 530 540 PCHFPCKFSS YEKYWCKWNN TGCQALPSQD EGPSKAFVNC DENSRLVSLT LNLVTRADEG 550 560 570 580 590 600 WYWCGVKQGH FYGETAAVYV AVEERKAAGS RDVSLAKADA APDEKVLDSG FREIENKAIQ 610 620 630 640 650 660 DPRLFAEEKA VADTRDQADG SRASVDSGSS EEQGGSSRAL VSTLVPLGLV LAVGAVAVGV 670 680 690 700 710 720 ARARHRKNVD RVSIRSYRTD ISMSDFENSR EFGANDNMGA SSITQETSLG GKEEFVATTE 730 740 750 760 STTETKEPKK AKRSSKEEAE MAYKDFLLQS STVAAEAQDG PQEA

CATM prediction

The sequence of PIGR_HUMAN returned 1 potential models

The positions at the dimer's interface are highlighted in yellow. The position at the crossing point is highlighted in orange.

# Sequence and interface d θ Z' ω' Score
      640       650       660  
    |    +    |    +    |    		 (Å) (°) (Å) (°)  
Model 1 SSRALVSTLVALGLVLAVGAVAVGVARAR 7.4 -46.3° 3.6 37.0 -0.8
Prolines* SSRALVSTLVPLGLVLAVGAVAVGVARAR          

* Note: this sequence contains Pro residues. CATM substituted them with Ala during the modeling. The positions are marked.

Click on the model number to visualize its details below.

MODEL 1 DETAILS

Precited structure:


Click on the image to enlarge

Download model 1 structure: PDB, PyMOL session

List of hydrogen bonds:

Donor Acceptor Distance
B, 651, LEU, HA A, 650, VAL, O 3.46Å
B, 654, GLY, HA1 A, 651, LEU, O 3.47Å
A, 651, LEU, HA B, 650, VAL, O 3.46Å
A, 654, GLY, HA1 B, 651, LEU, O 3.47Å