T-cell surface glycoprotein CD8 alpha chain

UniProt data

UniProt name: CD8A_HUMAN (P01732)

Gene name: CD8A; Synonyms=MAL

Organism: Homo sapiens (Human).

Function: Identifies cytotoxic/suppressor T-cells that interact with MHC class I bearing targets. CD8 is thought to play a role in the process of T-cell mediated killing. CD8 alpha chains binds to class I MHC molecules alpha-3 domains.

Subcellular location: Isoform 2: Secreted.

Transmembrane domains:

  1. 183-203, 21 AA, Helical. {ECO:0000255}.

Sequence: 235 AA

10 20 30 40 50 60 MALPVTALLL PLALLLHAAR PSQFRVSPLD RTWNLGETVE LKCQVLLSNP TSGCSWLFQP 70 80 90 100 110 120 RGAAASPTFL LYLSQNKPKA AEGLDTQRFS GKRLGDTFVL TLSDFRRENE GYYFCSALSN 130 140 150 160 170 180 SIMYFSHFVP VFLPAKPTTT PAPRPPTPAP TIASQPLSLR PEACRPAAGG AVHTRGLDFA 190 200 210 220 230 CDIYIWAPLA GTCGVLLLSL VITLYCNHRN RRRVCKCPRP VVKSGDKPSL SARYV

CATM prediction

The sequence of CD8A_HUMAN returned 3 potential models

The positions at the dimer's interface are highlighted in yellow. The position at the crossing point is highlighted in orange.

# Sequence and interface d θ Z' ω' Score
  180       190       200    
|    +    |    +    |    + 		 (Å) (°) (Å) (°)  
Model 1 ACDIYIWAALAGTCGVLLLSLVITLYC 7.3 -51.0° 3.3 47.8 -12.9
Model 2 ACDIYIWAALAGTCGVLLLSLVITLYC 7.0 +47.9° 2.0 -0.2 -7.6
Model 3 ACDIYIWAALAGTCGVLLLSLVITLYC 7.0 -49.0° 3.9 37.6 -3.7
Prolines* ACDIYIWAPLAGTCGVLLLSLVITLYC          

* Note: this sequence contains Pro residues. CATM substituted them with Ala during the modeling. The positions are marked.

Click on the model number to visualize its details below.

MODEL 1 DETAILS

Precited structure:


Click on the image to enlarge

Download model 1 structure: PDB, PyMOL session

List of hydrogen bonds:

Donor Acceptor Distance
B, 187, ALA, HA A, 184, TYR, OH 2.94Å
B, 188, ALA, HA A, 187, ALA, O 3.16Å
B, 191, GLY, HA1 A, 188, ALA, O 3.32Å
A, 187, ALA, HA B, 184, TYR, OH 2.94Å
A, 188, ALA, HA B, 187, ALA, O 3.16Å
A, 191, GLY, HA1 B, 188, ALA, O 3.32Å