T-cell surface glycoprotein CD4

UniProt data

UniProt name: CD4_HUMAN (P01730)

Gene name: CD4

Organism: Homo sapiens (Human).

Function: (Microbial infection) Acts as a receptor for human immunodeficiency virus-1 (PubMed:2214026, PubMed:16331979, PubMed:9641677). Down-regulated by HIV-1 Vpu (PubMed:17346169). Acts as a receptor for Human Herpes virus 7/HHV-7 (PubMed:7909607). {ECO:0000269|PubMed:16331979, ECO:0000269|PubMed:17346169, ECO:0000269|PubMed:2214026, ECO:0000269|PubMed:7909607, ECO:0000269|PubMed:9641677}.

Subcellular location: Cell membrane {ECO:0000269|PubMed:12517957}; Single-pass type I membrane protein {ECO:0000269|PubMed:12517957}. Note=Localizes to lipid rafts. Removed from plasma membrane by HIV-1 Nef protein that increases clathrin-dependent endocytosis of this antigen to target it to lysosomal degradation. Cell surface expression is also down-modulated by HIV-1 Envelope polyprotein gp160 that interacts with, and sequesters CD4 in the endoplasmic reticulum.

Transmembrane domains:

  1. 397-418, 22 AA, Helical. {ECO:0000255}.

Sequence: 458 AA

10 20 30 40 50 60 MNRGVPFRHL LLVLQLALLP AATQGKKVVL GKKGDTVELT CTASQKKSIQ FHWKNSNQIK 70 80 90 100 110 120 ILGNQGSFLT KGPSKLNDRA DSRRSLWDQG NFPLIIKNLK IEDSDTYICE VEDQKEEVQL 130 140 150 160 170 180 LVFGLTANSD THLLQGQSLT LTLESPPGSS PSVQCRSPRG KNIQGGKTLS VSQLELQDSG 190 200 210 220 230 240 TWTCTVLQNQ KKVEFKIDIV VLAFQKASSI VYKKEGEQVE FSFPLAFTVE KLTGSGELWW 250 260 270 280 290 300 QAERASSSKS WITFDLKNKE VSVKRVTQDP KLQMGKKLPL HLTLPQALPQ YAGSGNLTLA 310 320 330 340 350 360 LEAKTGKLHQ EVNLVVMRAT QLQKNLTCEV WGPTSPKLML SLKLENKEAK VSKREKAVWV 370 380 390 400 410 420 LNPEAGMWQC LLSDSGQVLL ESNIKVLPTW STPVQPMALI VLGGVAGLLL FIGLGIFFCV 430 440 450 RCRHRRRQAE RMSQIKRLLS EKKTCQCPHR FQKTCSPI

CATM prediction

The sequence of CD4_HUMAN returned 2 potential models

The positions at the dimer's interface are highlighted in yellow. The position at the crossing point is highlighted in orange.

# Sequence and interface d θ Z' ω' Score
        400       410       42
 +    |    +    |    +    | 		 (Å) (°) (Å) (°)  
Model 1 VQAMALIVLGGVAGLLLFIGLGIFFCVR 6.3 -51.0° 6.0 44.7 -24.0
Model 2 VQAMALIVLGGVAGLLLFIGLGIFFCVR 7.2 -55.0° 0.9 50.0 -1.3
Prolines* VQPMALIVLGGVAGLLLFIGLGIFFCVR          

* Note: this sequence contains Pro residues. CATM substituted them with Ala during the modeling. The positions are marked.

Click on the model number to visualize its details below.

MODEL 1 DETAILS

Precited structure:


Click on the image to enlarge

Download model 1 structure: PDB, PyMOL session

List of hydrogen bonds:

Donor Acceptor Distance
B, 400, ILE, HA A, 399, LEU, O 3.37Å
B, 403, GLY, HA1 A, 400, ILE, O 2.56Å
B, 404, GLY, HA2 A, 403, GLY, O 2.42Å
B, 407, GLY, HA1 A, 404, GLY, O 3.22Å
A, 400, ILE, HA B, 399, LEU, O 3.37Å
A, 403, GLY, HA1 B, 400, ILE, O 2.56Å
A, 404, GLY, HA2 B, 403, GLY, O 2.42Å
A, 407, GLY, HA1 B, 404, GLY, O 3.22Å