Interleukin-2 receptor subunit alpha

UniProt data

UniProt name: IL2RA_HUMAN (P01589)

Gene name: IL2RA

Organism: Homo sapiens (Human).

Function: Receptor for interleukin-2. The receptor is involved in the regulation of immune tolerance by controlling regulatory T cells (TREGs) activity. TREGs suppress the activation and expansion of autoreactive T-cells. {ECO:0000269|PubMed:23416241, ECO:0000269|PubMed:24116927}.

Subcellular location: Membrane; Single-pass type I membrane protein.

Transmembrane domains:

  1. 241-259, 19 AA, Helical. {ECO:0000255}.

Sequence: 272 AA

10 20 30 40 50 60 MDSYLLMWGL LTFIMVPGCQ AELCDDDPPE IPHATFKAMA YKEGTMLNCE CKRGFRRIKS 70 80 90 100 110 120 GSLYMLCTGN SSHSSWDNQC QCTSSATRNT TKQVTPQPEE QKERKTTEMQ SPMQPVDQAS 130 140 150 160 170 180 LPGHCREPPP WENEATERIY HFVVGQMVYY QCVQGYRALH RGPAESVCKM THGKTRWTQP 190 200 210 220 230 240 QLICTGEMET SQFPGEEKPQ ASPEGRPESE TSCLVTTTDF QIQTEMAATM ETSIFTTEYQ 250 260 270 VAVAGCVFLL ISVLLLSGLT WQRRQRKSRR TI

CATM prediction

The sequence of IL2RA_HUMAN returned 1 potential models

The positions at the dimer's interface are highlighted in yellow. The position at the crossing point is highlighted in orange.

# Sequence and interface d θ Z' ω' Score
    240       250       260
  |    +    |    +    |  		 (Å) (°) (Å) (°)  
Model 1 EYQVAVAGCVFLLISVLLLSGLTWQ 7.3 -48.1° 3.3 34.1 -6.8

Click on the model number to visualize its details below.

MODEL 1 DETAILS

Precited structure:


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Download model 1 structure: PDB, PyMOL session

List of hydrogen bonds:

Donor Acceptor Distance
B, 242, ALA, HA A, 241, VAL, O 3.48Å
B, 245, GLY, HA1 A, 242, ALA, O 3.42Å
A, 242, ALA, HA B, 241, VAL, O 3.48Å
A, 245, GLY, HA1 B, 242, ALA, O 3.42Å