Epidermal growth factor receptor

UniProt data

UniProt name: EGFR_HUMAN (P00533)

Gene name: EGFR; Synonyms=ERBB, ERBB1, HER1

Organism: Homo sapiens (Human).

Function: Isoform 2 may act as an antagonist of EGF action.

Subcellular location: Isoform 2: Secreted.

Transmembrane domains:

  1. 646-668, 23 AA, Helical. {ECO:0000255}.

Sequence: 1210 AA

10 20 30 40 50 60 MRPSGTAGAA LLALLAALCP ASRALEEKKV CQGTSNKLTQ LGTFEDHFLS LQRMFNNCEV 70 80 90 100 110 120 VLGNLEITYV QRNYDLSFLK TIQEVAGYVL IALNTVERIP LENLQIIRGN MYYENSYALA 130 140 150 160 170 180 VLSNYDANKT GLKELPMRNL QEILHGAVRF SNNPALCNVE SIQWRDIVSS DFLSNMSMDF 190 200 210 220 230 240 QNHLGSCQKC DPSCPNGSCW GAGEENCQKL TKIICAQQCS GRCRGKSPSD CCHNQCAAGC 250 260 270 280 290 300 TGPRESDCLV CRKFRDEATC KDTCPPLMLY NPTTYQMDVN PEGKYSFGAT CVKKCPRNYV 310 320 330 340 350 360 VTDHGSCVRA CGADSYEMEE DGVRKCKKCE GPCRKVCNGI GIGEFKDSLS INATNIKHFK 370 380 390 400 410 420 NCTSISGDLH ILPVAFRGDS FTHTPPLDPQ ELDILKTVKE ITGFLLIQAW PENRTDLHAF 430 440 450 460 470 480 ENLEIIRGRT KQHGQFSLAV VSLNITSLGL RSLKEISDGD VIISGNKNLC YANTINWKKL 490 500 510 520 530 540 FGTSGQKTKI ISNRGENSCK ATGQVCHALC SPEGCWGPEP RDCVSCRNVS RGRECVDKCN 550 560 570 580 590 600 LLEGEPREFV ENSECIQCHP ECLPQAMNIT CTGRGPDNCI QCAHYIDGPH CVKTCPAGVM 610 620 630 640 650 660 GENNTLVWKY ADAGHVCHLC HPNCTYGCTG PGLEGCPTNG PKIPSIATGM VGALLLLLVV 670 680 690 700 710 720 ALGIGLFMRR RHIVRKRTLR RLLQERELVE PLTPSGEAPN QALLRILKET EFKKIKVLGS 730 740 750 760 770 780 GAFGTVYKGL WIPEGEKVKI PVAIKELREA TSPKANKEIL DEAYVMASVD NPHVCRLLGI 790 800 810 820 830 840 CLTSTVQLIT QLMPFGCLLD YVREHKDNIG SQYLLNWCVQ IAKGMNYLED RRLVHRDLAA 850 860 870 880 890 900 RNVLVKTPQH VKITDFGLAK LLGAEEKEYH AEGGKVPIKW MALESILHRI YTHQSDVWSY 910 920 930 940 950 960 GVTVWELMTF GSKPYDGIPA SEISSILEKG ERLPQPPICT IDVYMIMVKC WMIDADSRPK 970 980 990 1000 1010 1020 FRELIIEFSK MARDPQRYLV IQGDERMHLP SPTDSNFYRA LMDEEDMDDV VDADEYLIPQ 1030 1040 1050 1060 1070 1080 QGFFSSPSTS RTPLLSSLSA TSNNSTVACI DRNGLQSCPI KEDSFLQRYS SDPTGALTED 1090 1100 1110 1120 1130 1140 SIDDTFLPVP EYINQSVPKR PAGSVQNPVY HNQPLNPAPS RDPHYQDPHS TAVGNPEYLN 1150 1160 1170 1180 1190 1200 TVQPTCVNST FDSPAHWAQK GSHQISLDNP DYQQDFFPKE AKPNGIFKGS TAENAEYLRV APQSSEFIGA

CATM prediction

The sequence of EGFR_HUMAN returned 3 potential models

The positions at the dimer's interface are highlighted in yellow. The position at the crossing point is highlighted in orange.

# Sequence and interface d θ Z' ω' Score
         650       660       67
  +    |    +    |    +    | 		 (Å) (°) (Å) (°)  
Model 1 IASIATGMVGALLLLLVVALGIGLFMRRR 7.0 -50.0° 2.9 47.0 -12.4
Model 2 IASIATGMVGALLLLLVVALGIGLFMRRR 7.1 -48.0° 3.3 34.1 -11.8
Model 3 IASIATGMVGALLLLLVVALGIGLFMRRR 7.4 -46.0° 2.7 46.8 -9.7
Prolines* IPSIATGMVGALLLLLVVALGIGLFMRRR          

* Note: this sequence contains Pro residues. CATM substituted them with Ala during the modeling. The positions are marked.

Click on the model number to visualize its details below.

MODEL 1 DETAILS

Precited structure:


Click on the image to enlarge

Download model 1 structure: PDB, PyMOL session

List of hydrogen bonds:

Donor Acceptor Distance
B, 649, GLY, HA1 A, 646, ILE, O 2.97Å
A, 649, GLY, HA1 B, 646, ILE, O 2.97Å