Peroxisomal membrane protein 11B

UniProt data

UniProt name: PX11B_HUMAN (O96011)

Gene name: PEX11B

Organism: Homo sapiens (Human).

Function: Involved in peroxisomal proliferation (PubMed:9792670). May regulate peroxisome division by recruiting the dynamin-related GTPase DNM1L to the peroxisomal membrane (PubMed:12618434). Promotes membrane protrusion and elongation on the peroxisomal surface (PubMed:20826455). {ECO:0000269|PubMed:12618434, ECO:0000269|PubMed:20826455, ECO:0000269|PubMed:9792670}.

Subcellular location: Peroxisome membrane {ECO:0000269|PubMed:10704444, ECO:0000269|PubMed:20826455, ECO:0000269|PubMed:9792670, ECO:0000269|PubMed:9826565}; Single- pass membrane protein {ECO:0000269|PubMed:10704444, ECO:0000269|PubMed:9792670, ECO:0000269|PubMed:9826565}.

Transmembrane domains:

  1. 233-255, 23 AA, Helical. {ECO:0000255}.

Sequence: 259 AA

10 20 30 40 50 60 MDAWVRFSAQ SQARERLCRA AQYACSLLGH ALQRHGASPE LQKQIRQLES HLSLGRKLLR 70 80 90 100 110 120 LGNSADALES AKRAVHLSDV VLRFCITVSH LNRALYFACD NVLWAGKSGL APRVDQEKWA 130 140 150 160 170 180 QRSFRYYLFS LIMNLSRDAY EIRLLMEQES SACSRRLKGS GGGVPGGSET GGLGGPGTPG 190 200 210 220 230 240 GGLPQLALKL RLQVLLLARV LRGHPPLLLD VVRNACDLFI PLDKLGLWRC GPGIVGLCGL 250 VSSILSILTL IYPWLRLKP

CATM prediction

The sequence of PX11B_HUMAN returned 2 potential models

The positions at the dimer's interface are highlighted in yellow. The position at the crossing point is highlighted in orange.

# Sequence and interface d θ Z' ω' Score
  230       240       250      
|    +    |    +    |    +   		 (Å) (°) (Å) (°)  
Model 1 CGAGIVGLCGLVSSILSILTLIYAWLRLK 7.1 +52.0° 1.8 1.0 -5.4
Model 2 CGAGIVGLCGLVSSILSILTLIYAWLRLK 7.2 -44.0° 1.8 45.1 -4.4
Prolines* CGPGIVGLCGLVSSILSILTLIYPWLRLK          

* Note: this sequence contains Pro residues. CATM substituted them with Ala during the modeling. The positions are marked.

Click on the model number to visualize its details below.

MODEL 1 DETAILS

Precited structure:


Click on the image to enlarge

Download model 1 structure: PDB, PyMOL session

List of hydrogen bonds:

Donor Acceptor Distance
B, 236, GLY, HA2 A, 235, VAL, O 3.43Å
A, 236, GLY, HA2 B, 235, VAL, O 3.43Å