Natural cytotoxicity triggering receptor 2

UniProt data

UniProt name: NCTR2_HUMAN (O95944)

Gene name: NCR2; Synonyms=LY95

Organism: Homo sapiens (Human).

Function: Cytotoxicity-activating receptor that may contribute to the increased efficiency of activated natural killer (NK) cells to mediate tumor cell lysis. {ECO:0000269|PubMed:10049942}.

Subcellular location: Cell membrane {ECO:0000305}; Single-pass type I membrane protein {ECO:0000305}.

Transmembrane domains:

  1. 193-213, 21 AA, Helical. {ECO:0000255}.

Sequence: 276 AA

10 20 30 40 50 60 MAWRALHPLL LLLLLFPGSQ AQSKAQVLQS VAGQTLTVRC QYPPTGSLYE KKGWCKEASA 70 80 90 100 110 120 LVCIRLVTSS KPRTMAWTSR FTIWDDPDAG FFTVTMTDLR EEDSGHYWCR IYRPSDNSVS 130 140 150 160 170 180 KSVRFYLVVS PASASTQTSW TPRDLVSSQT QTQSCVPPTA GARQAPESPS TIPVPSQPQN 190 200 210 220 230 240 STLRPGPAAP IALVPVFCGL LVAKSLVLSA LLVWWGDIWW KTMMELRSLD TQKATCHLQQ 250 260 270 VTDLPWTSVS SPVEREILYH TVARTKISDD DDEHTL

CATM prediction

The sequence of NCTR2_HUMAN returned 1 potential models

The positions at the dimer's interface are highlighted in yellow. The position at the crossing point is highlighted in orange.

# Sequence and interface d θ Z' ω' Score
  190       200       210    
|    +    |    +    |    + 		 (Å) (°) (Å) (°)  
Model 1 AIALVAVFCGLLVAKSLVLSALLVWWG 6.9 -45.8° 2.7 47.2 -24.4
Prolines* PIALVPVFCGLLVAKSLVLSALLVWWG          

* Note: this sequence contains Pro residues. CATM substituted them with Ala during the modeling. The positions are marked.

Click on the model number to visualize its details below.

MODEL 1 DETAILS

Precited structure:


Click on the image to enlarge

Download model 1 structure: PDB, PyMOL session

List of hydrogen bonds:

Donor Acceptor Distance
B, 196, VAL, HA A, 195, ALA, O 2.91Å
B, 199, GLY, HA1 A, 196, VAL, O 2.87Å
B, 200, LEU, HA A, 199, GLY, O 3.45Å
A, 196, VAL, HA B, 195, ALA, O 2.91Å
A, 199, GLY, HA1 B, 196, VAL, O 2.87Å
A, 200, LEU, HA B, 199, GLY, O 3.45Å