Protein G6b

UniProt data

UniProt name: G6B_HUMAN (O95866)

Gene name: G6B {ECO:0000312|EMBL:CAC83497.1}

Organism: Homo sapiens (Human).

Function: Inhibits platelet aggregation and activation by agonists such as ADP and collagen-related peptide. Appears to operate in a calcium-independent manner. Isoform B is a putative inhibitory receptor. Isoform A may be its activating counterpart. {ECO:0000269|PubMed:17311996}.

Subcellular location: Isoform A: Cell membrane; Single-pass type I membrane protein.

Transmembrane domains:

  1. 143-163, 21 AA, Helical. {ECO:0000255}.

Sequence: 241 AA

10 20 30 40 50 60 MAVFLQLLPL LLSRAQGNPG ASLDGRPGDR VNLSCGGVSH PIRWVWAPSF PACKGLSKGR 70 80 90 100 110 120 RPILWASSSG TPTVPPLQPF VGRLRSLDSG IRRLELLLSA GDSGTFFCKG RHEDESRTVL 130 140 150 160 170 180 HVLGDRTYCK APGPTHGSVY PQLLIPLLGA GLVLGLGALG LVWWLHRRLP PQPIRPLPRF 190 200 210 220 230 240 APLVKTEPQR PVKEEEPKIP GDLDQEPSLL YADLDHLALS RPRRLSTADP ADASTIYAVV V

CATM prediction

The sequence of G6B_HUMAN returned 3 potential models

The positions at the dimer's interface are highlighted in yellow. The position at the crossing point is highlighted in orange.

# Sequence and interface d θ Z' ω' Score
  140       150       160    
|    +    |    +    |    + 		 (Å) (°) (Å) (°)  
Model 1 YAQLLIALLGAGLVLGLGALGLVWWLH 6.7 -55.2° 1.5 45.0 -22.4
Model 2 YAQLLIALLGAGLVLGLGALGLVWWLH 7.0 +54.0° 3.3 80.1 -9.1
Model 3 YAQLLIALLGAGLVLGLGALGLVWWLH 7.3 -55.0° 2.4 48.2 -3.1
Prolines* YPQLLIPLLGAGLVLGLGALGLVWWLH          

* Note: this sequence contains Pro residues. CATM substituted them with Ala during the modeling. The positions are marked.

Click on the model number to visualize its details below.

MODEL 1 DETAILS

Precited structure:


Click on the image to enlarge

Download model 1 structure: PDB, PyMOL session

List of hydrogen bonds:

Donor Acceptor Distance
B, 148, LEU, HA A, 147, LEU, O 3.27Å
B, 151, GLY, HA1 A, 148, LEU, O 2.67Å
B, 152, LEU, HA A, 151, GLY, O 3.17Å
A, 148, LEU, HA B, 147, LEU, O 3.27Å
A, 151, GLY, HA1 B, 148, LEU, O 2.67Å
A, 152, LEU, HA B, 151, GLY, O 3.17Å