UniProt data
UniProt name: SEM4F_HUMAN (O95754)
Gene name: SEMA4F; Synonyms=SEMAM, SEMAW
Organism: Homo sapiens (Human).
Function: Has growth cone collapse activity against retinal ganglion-cell axons. {ECO:0000250}.
Subcellular location: Membrane; Single-pass type I membrane protein.
Transmembrane domains:
- 660-680, 21 AA, Helical. {ECO:0000255}.
Sequence: 770 AA
10 20 30 40 50 60
MPASAARPRP GPGQPTASPF PLLLLAVLSG PVSGRVPRSV PRTSLPISEA DSCLTRFAVP
70 80 90 100 110 120
HTYNYSVLLV DPASHTLYVG ARDTIFALSL PFSGERPRRI DWMVPEAHRQ NCRKKGKKED
130 140 150 160 170 180
ECHNFVQILA IANASHLLTC GTFAFDPKCG VIDVSRFQQV ERLESGRGKC PFEPAQRSAA
190 200 210 220 230 240
VMAGGVLYAA TVKNYLGTEP IITRAVGRAE DWIRTDTLPS WLNAPAFVAA VALSPAEWGD
250 260 270 280 290 300
EDGDDEIYFF FTETSRAFDS YERIKVPRVA RVCAGDLGGR KTLQQRWTTF LKADLLCPGP
310 320 330 340 350 360
EHGRASSVLQ DVAVLRPELG AGTPIFYGIF SSQWEGATIS AVCAFRPQDI RTVLNGPFRE
370 380 390 400 410 420
LKHDCNRGLP VVDNDVPQPR PGECITNNMK LRHFGSSLSL PDRVLTFIRD HPLMDRPVFP
430 440 450 460 470 480
ADGHPLLVTT DTAYLRVVAH RVTSLSGKEY DVLYLGTEDG HLHRAVRIGA QLSVLEDLAL
490 500 510 520 530 540
FPEPQPVENM KLYHSWLLVG SRTEVTQVNT TNCGRLQSCS ECILAQDPVC AWSFRLDECV
550 560 570 580 590 600
AHAGEHRGLV QDIESADVSS LCPKEPGERP VVFEVPVATA AHVVLPCSPS SAWASCVWHQ
610 620 630 640 650 660
PSGVTALTPR RDGLEVVVTP GAMGAYACEC QEGGAAHVVA AYSLVWGSQR DAPSRAHTVG
670 680 690 700 710 720
AGLAGFFLGI LAASLTLILI GRRQQRRRQR ELLARDKVGL DLGAPPSGTT SYSQDPPSPS
730 740 750 760
PEDERLPLAL AKRGSGFGGF SPPFLLDPCP SPAHIRLTGA PLATCDETSI
CATM prediction
The sequence of SEM4F_HUMAN returned 5 potential models
The positions at the dimer's interface are highlighted in yellow. The position at the crossing point is highlighted in orange.
| # | Sequence and interface | d | θ | Z' | ω' | Score |
|---|---|---|---|---|---|---|
| 660 670 680 | + | + | |
(Å) | (°) | (Å) | (°) | ||
| Model 1 | HTVGAGLAGFFLGILAASLTLILIGRR | 6.6 | -40.6° | 0.6 | 43.6 | -40.6 |
| Model 2 | HTVGAGLAGFFLGILAASLTLILIGRR | 6.8 | -31.8° | 2.9 | 49.9 | -32.9 |
| Model 3 | HTVGAGLAGFFLGILAASLTLILIGRR | 7.2 | -42.8° | 3.4 | 50.3 | -16.3 |
| Model 4 | HTVGAGLAGFFLGILAASLTLILIGRR | 6.8 | -51.2° | 1.8 | 59.8 | -13.3 |
| Model 5 | HTVGAGLAGFFLGILAASLTLILIGRR | 7.0 | +51.2° | 3.9 | 72.0 | -6.9 |
Click on the model number to visualize its details below.
MODEL 1 DETAILS
Precited structure:
Click on the image to enlarge
Download model 1 structure: PDB, PyMOL session
List of hydrogen bonds:
| Donor | Acceptor | Distance |
|---|---|---|
| B, 662, GLY, HA2 | A, 661, ALA, O | 3.09Å |
| B, 665, GLY, HA1 | A, 662, GLY, O | 2.68Å |
| B, 666, PHE, HA | A, 665, GLY, O | 2.53Å |
| B, 669, GLY, HA1 | A, 666, PHE, O | 3.31Å |
| A, 662, GLY, HA2 | B, 661, ALA, O | 3.09Å |
| A, 665, GLY, HA1 | B, 662, GLY, O | 2.68Å |
| A, 666, PHE, HA | B, 665, GLY, O | 2.53Å |
| A, 669, GLY, HA1 | B, 666, PHE, O | 3.31Å |
