Endothelin-converting enzyme-like 1

UniProt data

UniProt name: ECEL1_HUMAN (O95672)

Gene name: ECEL1; Synonyms=XCE; ORFNames=UNQ2431/PRO4991

Organism: Homo sapiens (Human).

Function: May contribute to the degradation of peptide hormones and be involved in the inactivation of neuronal peptides.

Subcellular location: Membrane {ECO:0000250}; Single-pass type II membrane protein {ECO:0000250}.

Transmembrane domains:

  1. 60-82, 23 AA, Helical; Signal-anchor for type II membrane protein. {ECO:0000255}.

Sequence: 775 AA

10 20 30 40 50 60 MEPPYSLTAH YDEFQEVKYV SRCGAGGARG ASLPPGFPLG AARSATGARS GLPRWNRREV 70 80 90 100 110 120 CLLSGLVFAA GLCAILAAML ALKYLGPVAA GGGACPEGCP ERKAFARAAR FLAANLDASI 130 140 150 160 170 180 DPCQDFYSFA CGGWLRRHAI PDDKLTYGTI AAIGEQNEER LRRLLARPGG GPGGAAQRKV 190 200 210 220 230 240 RAFFRSCLDM REIERLGPRP MLEVIEDCGG WDLGGAEERP GVAARWDLNR LLYKAQGVYS 250 260 270 280 290 300 AAALFSLTVS LDDRNSSRYV IRIDQDGLTL PERTLYLAQD EDSEKILAAY RVFMERVLSL 310 320 330 340 350 360 LGADAVEQKA QEILQVEQQL ANITVSEHDD LRRDVSSMYN KVTLGQLQKI TPHLRWKWLL 370 380 390 400 410 420 DQIFQEDFSE EEEVVLLATD YMQQVSQLIR STPHRVLHNY LVWRVVVVLS EHLSPPFREA 430 440 450 460 470 480 LHELAQEMEG SDKPQELARV CLGQANRHFG MALGALFVHE HFSAASKAKV QQLVEDIKYI 490 500 510 520 530 540 LGQRLEELDW MDAETRAAAR AKLQYMMVMV GYPDFLLKPD AVDKEYEFEV HEKTYFKNIL 550 560 570 580 590 600 NSIRFSIQLS VKKIRQEVDK STWLLPPQAL NAYYLPNKNQ MVFPAGILQP TLYDPDFPQS 610 620 630 640 650 660 LNYGGIGTII GHELTHGYDD WGGQYDRSGN LLHWWTEASY SRFLRKAECI VRLYDNFTVY 670 680 690 700 710 720 NQRVNGKHTL GENIADMGGL KLAYHAYQKW VREHGPEHPL PRLKYTHDQL FFIAFAQNWC 730 740 750 760 770 IKRRSQSIYL QVLTDKHAPE HYRVLGSVSQ FEEFGRAFHC PKDSPMNPAH KCSVW

CATM prediction

The sequence of ECEL1_HUMAN returned 2 potential models

The positions at the dimer's interface are highlighted in yellow. The position at the crossing point is highlighted in orange.

# Sequence and interface d θ Z' ω' Score
     60        70        80    
   |    +    |    +    |    +		 (Å) (°) (Å) (°)  
Model 1 RREVCLLSGLVFAAGLCAILAAMLALKYL 7.2 -43.2° 2.4 44.1 -29.0
Model 2 RREVCLLSGLVFAAGLCAILAAMLALKYL 7.4 -54.0° 3.6 49.0 -11.4

Click on the model number to visualize its details below.

MODEL 1 DETAILS

Precited structure:


Click on the image to enlarge

Download model 1 structure: PDB, PyMOL session

List of hydrogen bonds:

Donor Acceptor Distance
B, 62, LEU, HA A, 61, CYS, O 3.25Å
B, 65, GLY, HA1 A, 62, LEU, O 3.15Å
B, 66, LEU, HA A, 65, GLY, O 3.49Å
A, 62, LEU, HA B, 61, CYS, O 3.25Å
A, 65, GLY, HA1 B, 62, LEU, O 3.15Å
A, 66, LEU, HA B, 65, GLY, O 3.49Å