Neuronal pentraxin receptor

UniProt data

UniProt name: NPTXR_HUMAN (O95502)

Gene name: NPTXR

Organism: Homo sapiens (Human).

Function: May be involved in mediating uptake of synaptic material during synapse remodeling or in mediating the synaptic clustering of AMPA glutamate receptors at a subset of excitatory synapses. {ECO:0000250}.

Subcellular location: Membrane {ECO:0000305}; Single-pass type II membrane protein {ECO:0000305}.

Transmembrane domains:

  1. 3-23, 21 AA, Helical; Signal-anchor for type II membrane protein. {ECO:0000255}.

Sequence: 500 AA

10 20 30 40 50 60 MKFLAVLLAA GMLAFLGAVI CIIASVPLAA SPARALPGGA DNASVASGAA ASPGPQRSLS 70 80 90 100 110 120 ALHGAGGSAG PPALPGAPAA SAHPLPPGPL FSRFLCTPLA AACPSGAQQG DAAGAAPGER 130 140 150 160 170 180 EELLLLQSTA EQLRQTALQQ EARIRADQDT IRELTGKLGR CESGLPRGLQ GAGPRRDTMA 190 200 210 220 230 240 DGPWDSPALI LELEDAVRAL RDRIDRLEQE LPARVNLSAA PAPVSAVPTG LHSKMDQLEG 250 260 270 280 290 300 QLLAQVLALE KERVALSHSS RRQRQEVEKE LDVLQGRVAE LEHGSSAYSP PDAFKISIPI 310 320 330 340 350 360 RNNYMYARVR KALPELYAFT ACMWLRSRSS GTGQGTPFSY SVPGQANEIV LLEAGHEPME 370 380 390 400 410 420 LLINDKVAQL PLSLKDNGWH HICIAWTTRD GLWSAYQDGE LQGSGENLAA WHPIKPHGIL 430 440 450 460 470 480 ILGQEQDTLG GRFDATQAFV GDIAQFNLWD HALTPAQVLG IANCTAPLLG NVLPWEDKLV 490 EAFGGATKAA FDVCKGRAKA

CATM prediction

The sequence of NPTXR_HUMAN returned 2 potential models

The positions at the dimer's interface are highlighted in yellow. The position at the crossing point is highlighted in orange.

# Sequence and interface d θ Z' ω' Score
           10        20     
    +    |    +    |    + 		 (Å) (°) (Å) (°)  
Model 1 MKFLAVLLAAGMLAFLGAVICIIASV 7.0 -52.9° 2.0 44.8 -23.6
Model 2 MKFLAVLLAAGMLAFLGAVICIIASV 7.0 -55.0° 1.5 45.1 -4.7

Click on the model number to visualize its details below.

MODEL 1 DETAILS

Precited structure:


Click on the image to enlarge

Download model 1 structure: PDB, PyMOL session

List of hydrogen bonds:

Donor Acceptor Distance
B, 14, ALA, HA A, 13, LEU, O 3.30Å
B, 17, GLY, HA1 A, 14, ALA, O 2.94Å
A, 14, ALA, HA B, 13, LEU, O 3.30Å
A, 17, GLY, HA1 B, 14, ALA, O 2.94Å