Myelin protein zero-like protein 1

UniProt data

UniProt name: MPZL1_HUMAN (O95297)

Gene name: MPZL1; Synonyms=PZR; ORFNames=UNQ849/PRO1787

Organism: Homo sapiens (Human).

Function: Cell surface receptor, which is involved in signal transduction processes. Recruits PTPN11/SHP-2 to the cell membrane and is a putative substrate of PTPN11/SHP-2. Is a major receptor for concanavalin-A (ConA) and is involved in cellular signaling induced by ConA, which probably includes Src family tyrosine- protein kinases. Isoform 3 seems to have a dominant negative role; it blocks tyrosine phosphorylation of MPZL1 induced by ConA. Isoform 1, but not isoform 2 and isoform 3, may be involved in regulation of integrin-mediated cell motility. {ECO:0000269|PubMed:11751924, ECO:0000269|PubMed:12410637}.

Subcellular location: Membrane {ECO:0000305}; Single-pass type I membrane protein {ECO:0000305}.

Transmembrane domains:

  1. 163-183, 21 AA, Helical. {ECO:0000255}.

Sequence: 269 AA

10 20 30 40 50 60 MAASAGAGAV IAAPDSRRWL WSVLAAALGL LTAGVSALEV YTPKEIFVAN GTQGKLTCKF 70 80 90 100 110 120 KSTSTTGGLT SVSWSFQPEG ADTTVSFFHY SQGQVYLGNY PPFKDRISWA GDLDKKDASI 130 140 150 160 170 180 NIENMQFIHN GTYICDVKNP PDIVVQPGHI RLYVVEKENL PVFPVWVVVG IVTAVVLGLT 190 200 210 220 230 240 LLISMILAVL YRRKNSKRDY TGCSTSESLS PVKQAPRKSP SDTEGLVKSL PSGSHQGPVI 250 260 YAQLDHSGGH HSDKINKSES VVYADIRKN

CATM prediction

The sequence of MPZL1_HUMAN returned 1 potential models

The positions at the dimer's interface are highlighted in yellow. The position at the crossing point is highlighted in orange.

# Sequence and interface d θ Z' ω' Score
  160       170       180    
|    +    |    +    |    + 		 (Å) (°) (Å) (°)  
Model 1 LAVFAVWVVVGIVTAVVLGLTLLISMI 7.2 -47.1° 2.3 44.8 -28.7
Prolines* LPVFPVWVVVGIVTAVVLGLTLLISMI          

* Note: this sequence contains Pro residues. CATM substituted them with Ala during the modeling. The positions are marked.

Click on the model number to visualize its details below.

MODEL 1 DETAILS

Precited structure:


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Download model 1 structure: PDB, PyMOL session

List of hydrogen bonds:

Donor Acceptor Distance
B, 167, VAL, HA A, 166, TRP, O 3.38Å
B, 170, GLY, HA1 A, 167, VAL, O 3.10Å
B, 171, ILE, HA A, 170, GLY, O 3.39Å
A, 167, VAL, HA B, 166, TRP, O 3.38Å
A, 170, GLY, HA1 B, 167, VAL, O 3.10Å
A, 171, ILE, HA B, 170, GLY, O 3.39Å