Vesicle-associated membrane protein-associated protein B/C

UniProt data

UniProt name: VAPB_HUMAN (O95292)

Gene name: VAPB; ORFNames=UNQ484/PRO983

Organism: Homo sapiens (Human).

Function: Participates in the endoplasmic reticulum unfolded protein response (UPR) by inducing ERN1/IRE1 activity. Involved in cellular calcium homeostasis regulation. {ECO:0000269|PubMed:16891305, ECO:0000269|PubMed:20940299, ECO:0000269|PubMed:22131369}.

Subcellular location: Endoplasmic reticulum membrane {ECO:0000250}; Single-pass type IV membrane protein {ECO:0000250}. Note=Present in mitochondria-associated membranes that are endoplasmic reticulum membrane regions closely apposed to the outer mitochondrial membrane. {ECO:0000269|PubMed:22131369}.

Transmembrane domains:

  1. 223-243, 21 AA, Helical; Anchor for type IV membrane protein. {ECO:0000255}.

Sequence: 243 AA

10 20 30 40 50 60 MAKVEQVLSL EPQHELKFRG PFTDVVTTNL KLGNPTDRNV CFKVKTTAPR RYCVRPNSGI 70 80 90 100 110 120 IDAGASINVS VMLQPFDYDP NEKSKHKFMV QSMFAPTDTS DMEAVWKEAK PEDLMDSKLR 130 140 150 160 170 180 CVFELPAEND KPHDVEINKI ISTTASKTET PIVSKSLSSS LDDTEVKKVM EECKRLQGEV 190 200 210 220 230 240 QRLREENKQF KEEDGLRMRK TVQSNSPISA LAPTGKEEGL STRLLALVVL FFIVGVIIGK IAL

CATM prediction

The sequence of VAPB_HUMAN returned 1 potential models

The positions at the dimer's interface are highlighted in yellow. The position at the crossing point is highlighted in orange.

# Sequence and interface d θ Z' ω' Score
  220       230       240 
|    +    |    +    |   		 (Å) (°) (Å) (°)  
Model 1 LSTRLLALVVLFFIVGVIIGKIAL 7.2 -55.1° 0.9 50.6 -5.5

Click on the model number to visualize its details below.

MODEL 1 DETAILS

Precited structure:


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Download model 1 structure: PDB, PyMOL session

List of hydrogen bonds:

Donor Acceptor Distance
B, 235, GLY, HA1 A, 232, PHE, O 2.98Å
B, 236, VAL, HA A, 235, GLY, O 3.39Å
A, 235, GLY, HA1 B, 232, PHE, O 2.98Å
A, 236, VAL, HA B, 235, GLY, O 3.39Å