Interleukin-18 receptor accessory protein

UniProt data

UniProt name: I18RA_HUMAN (O95256)

Gene name: IL18RAP; Synonyms=IL1R7

Organism: Homo sapiens (Human).

Function: Within the IL18 receptor complex, does not mediate IL18- binding, but involved in IL18-dependent signal transduction, leading to NF-kappa-B and JNK activation. {ECO:0000269|PubMed:9792649, ECO:0000305}.

Subcellular location: Membrane {ECO:0000305}; Single-pass type I membrane protein {ECO:0000305}.

Transmembrane domains:

  1. 357-377, 21 AA, Helical. {ECO:0000255}.

Sequence: 599 AA

10 20 30 40 50 60 MLCLGWIFLW LVAGERIKGF NISGCSTKKL LWTYSTRSEE EFVLFCDLPE PQKSHFCHRN 70 80 90 100 110 120 RLSPKQVPEH LPFMGSNDLS DVQWYQQPSN GDPLEDIRKS YPHIIQDKCT LHFLTPGVNN 130 140 150 160 170 180 SGSYICRPKM IKSPYDVACC VKMILEVKPQ TNASCEYSAS HKQDLLLGST GSISCPSLSC 190 200 210 220 230 240 QSDAQSPAVT WYKNGKLLSV ERSNRIVVDE VYDYHQGTYV CDYTQSDTVS SWTVRAVVQV 250 260 270 280 290 300 RTIVGDTKLK PDILDPVEDT LEVELGKPLT ISCKARFGFE RVFNPVIKWY IKDSDLEWEV 310 320 330 340 350 360 SVPEAKSIKS TLKDEIIERN IILEKVTQRD LRRKFVCFVQ NSIGNTTQSV QLKEKRGVVL 370 380 390 400 410 420 LYILLGTIGT LVAVLAASAL LYRHWIEIVL LYRTYQSKDQ TLGDKKDFDA FVSYAKWSSF 430 440 450 460 470 480 PSEATSSLSE EHLALSLFPD VLENKYGYSL CLLERDVAPG GVYAEDIVSI IKRSRRGIFI 490 500 510 520 530 540 LSPNYVNGPS IFELQAAVNL ALDDQTLKLI LIKFCYFQEP ESLPHLVKKA LRVLPTVTWR 550 560 570 580 590 GLKSVPPNSR FWAKMRYHMP VKNSQGFTWN QLRITSRIFQ WKGLSRTETT GRSSQPKEW

CATM prediction

The sequence of I18RA_HUMAN returned 2 potential models

The positions at the dimer's interface are highlighted in yellow. The position at the crossing point is highlighted in orange.

# Sequence and interface d θ Z' ω' Score
        360       370       3
 +    |    +    |    +    |		 (Å) (°) (Å) (°)  
Model 1 EKRGVVLLYILLGTIGTLVAVLAASAL 7.2 -49.0° 1.8 45.2 -21.8
Model 2 EKRGVVLLYILLGTIGTLVAVLAASAL 7.4 -43.7° 0.9 45.8 -10.2

Click on the model number to visualize its details below.

MODEL 1 DETAILS

Precited structure:


Click on the image to enlarge

Download model 1 structure: PDB, PyMOL session

List of hydrogen bonds:

Donor Acceptor Distance
B, 366, GLY, HA2 A, 365, LEU, O 3.49Å
B, 369, GLY, HA1 A, 366, GLY, O 3.14Å
B, 370, THR, HA A, 369, GLY, O 3.48Å
A, 366, GLY, HA2 B, 365, LEU, O 3.49Å
A, 369, GLY, HA1 B, 366, GLY, O 3.14Å
A, 370, THR, HA B, 369, GLY, O 3.48Å