Golgi SNAP receptor complex member 1

UniProt data

UniProt name: GOSR1_HUMAN (O95249)

Gene name: GOSR1; Synonyms=GS28

Organism: Homo sapiens (Human).

Function: Involved in transport from the ER to the Golgi apparatus as well as in intra-Golgi transport. It belongs to a super-family of proteins called t-SNAREs or soluble NSF (N-ethylmaleimide- sensitive factor) attachment protein receptor. May play a protective role against hydrogen peroxide induced cytotoxicity under glutathione depleted conditions in neuronal cells by regulating the intracellular ROS levels via inhibition of p38 MAPK (MAPK11, MAPK12, MAPK13 and MAPK14). Participates in docking and fusion stage of ER to cis-Golgi transport. Plays an important physiological role in VLDL-transport vesicle-Golgi fusion and thus in VLDL delivery to the hepatic cis-Golgi. {ECO:0000269|PubMed:15215310, ECO:0000269|PubMed:21860593}.

Subcellular location: Golgi apparatus membrane {ECO:0000269|PubMed:15215310, ECO:0000269|PubMed:15728195, ECO:0000269|PubMed:17274796, ECO:0000269|PubMed:17337506, ECO:0000269|PubMed:21669198}; Single-pass type IV membrane protein {ECO:0000269|PubMed:15215310, ECO:0000269|PubMed:15728195, ECO:0000269|PubMed:17274796, ECO:0000269|PubMed:17337506, ECO:0000269|PubMed:21669198}. Note=Localizes throughout the Golgi apparatus, with lowest levels in the trans-Golgi network (By similarity). Enriched on vesicular components at the terminal rims of the Golgi. Found in Golgi microtubules at low temperature (15 degrees Celsius). {ECO:0000250}.

Transmembrane domains:

  1. 230-250, 21 AA, Helical; Anchor for type IV membrane protein. {ECO:0000255}.

Sequence: 250 AA

10 20 30 40 50 60 MAAGTSSYWE DLRKQARQLE NELDLKLVSF SKLCTSYSHS STRDGRRDRY SSDTTPLLNG 70 80 90 100 110 120 SSQDRMFETM AIEIEQLLAR LTGVNDKMAE YTNSAGVPSL NAALMHTLQR HRDILQDYTH 130 140 150 160 170 180 EFHKTKANFM AIRERENLMG SVRKDIESYK SGSGVNNRRT ELFLKEHDHL RNSDRLIEET 190 200 210 220 230 240 ISIAMATKEN MTSQRGMLKS IHSKMNTLAN RFPAVNSLIQ RINLRKRRDS LILGGVIGIC TILLLLYAFH

CATM prediction

The sequence of GOSR1_HUMAN returned 2 potential models

The positions at the dimer's interface are highlighted in yellow. The position at the crossing point is highlighted in orange.

# Sequence and interface d θ Z' ω' Score
     230       240       2
   |    +    |    +    |		 (Å) (°) (Å) (°)  
Model 1 RRDSLILGGVIGICTILLLLYAFH 6.5 -43.9° 1.8 45.0 -19.2
Model 2 RRDSLILGGVIGICTILLLLYAFH 7.1 -26.0° 3.6 54.0 -8.5

Click on the model number to visualize its details below.

MODEL 1 DETAILS

Precited structure:


Click on the image to enlarge

Download model 1 structure: PDB, PyMOL session

List of hydrogen bonds:

Donor Acceptor Distance
B, 231, LEU, HA A, 230, SER, O 2.70Å
B, 234, GLY, HA1 A, 231, LEU, O 2.50Å
B, 235, GLY, HA2 A, 234, GLY, O 2.85Å
A, 231, LEU, HA B, 230, SER, O 2.70Å
A, 234, GLY, HA1 B, 231, LEU, O 2.50Å
A, 235, GLY, HA2 B, 234, GLY, O 2.85Å