Starch-binding domain-containing protein 1 {ECO:0000303|PubMed:20810658}

UniProt data

UniProt name: STBD1_HUMAN (O95210)

Gene name: STBD1 {ECO:0000303|PubMed:20810658}; ORFNames=GENX-3414

Organism: Homo sapiens (Human).

Function: Acts as a cargo receptor for glycogen. Delivers its cargo to an autophagic pathway called glycophagy, resulting in the transport of glycogen to lysosomes. {ECO:0000269|PubMed:20810658, ECO:0000269|PubMed:21893048, ECO:0000269|PubMed:24837458}.

Subcellular location: Preautophagosomal structure membrane {ECO:0000269|PubMed:20810658, ECO:0000305|PubMed:21893048}; Single-pass type III membrane protein {ECO:0000305|PubMed:9794794}. Endoplasmic reticulum membrane {ECO:0000269|PubMed:24837458}; Single-pass type III membrane protein {ECO:0000305|PubMed:9794794}. Note=Distributed in the transverse tubules and/or near the junctional sarcoplasmic reticulum (PubMed:9794794). Concentrates at perinuclear structures (PubMed:21893048). {ECO:0000269|PubMed:21893048, ECO:0000269|PubMed:9794794}.

Transmembrane domains:

  1. 7-23, 17 AA, Helical. {ECO:0000255}.

Sequence: 358 AA

10 20 30 40 50 60 MGAVWSALLV GGGLAGALFV WLLRGGPGDT GKDGDAEQEK DAPLGGAAIP GGHQSGSSGL 70 80 90 100 110 120 SPGPSGQELV TKPEHLQESN GHLISKTKDL GKLQAASWRL QNPSREVCDN SREHVPSGQF 130 140 150 160 170 180 PDTEAPATSE TSNSRSYSEV SRNESLESPM GEWGFQKGQE ISAKAATCFA EKLPSSNLLK 190 200 210 220 230 240 NRAKEEMSLS DLNSQDRVDH EEWEMVPRHS SWGDVGVGGS LKAPVLNLNQ GMDNGRSTLV 250 260 270 280 290 300 EARGQQVHGK MERVAVMPAG SQQVSVRFQV HYVTSTDVQF IAVTGDHECL GRWNTYIPLH 310 320 330 340 350 YNKDGFWSHS IFLPADTVVE WKFVLVENGG VTRWEECSNR FLETGHEDKV VHAWWGIH

CATM prediction

The sequence of STBD1_HUMAN returned 2 potential models

The positions at the dimer's interface are highlighted in yellow. The position at the crossing point is highlighted in orange.

# Sequence and interface d θ Z' ω' Score
        10        20     
 +    |    +    |    + 		 (Å) (°) (Å) (°)  
Model 1 VWSALLVGGGLAGALFVWLLRGG 6.8 -43.0° 5.5 34.1 -18.7
Model 2 VWSALLVGGGLAGALFVWLLRGG 6.8 -43.9° 1.8 44.7 -17.6

Click on the model number to visualize its details below.

MODEL 1 DETAILS

Precited structure:


Click on the image to enlarge

Download model 1 structure: PDB, PyMOL session

List of hydrogen bonds:

Donor Acceptor Distance
B, 12, GLY, HA1 A, 9, LEU, O 3.27Å
B, 13, GLY, HA2 A, 12, GLY, O 2.77Å
B, 16, GLY, HA1 A, 13, GLY, O 3.13Å
A, 12, GLY, HA1 B, 9, LEU, O 3.27Å
A, 13, GLY, HA2 B, 12, GLY, O 2.77Å
A, 16, GLY, HA1 B, 13, GLY, O 3.13Å