Netrin receptor UNC5C

UniProt data

UniProt name: UNC5C_HUMAN (O95185)

Gene name: UNC5C; Synonyms=UNC5H3

Organism: Homo sapiens (Human).

Function: Receptor for netrin required for axon guidance. Mediates axon repulsion of neuronal growth cones in the developing nervous system upon ligand binding. Axon repulsion in growth cones may be caused by its association with DCC that may trigger signaling for repulsion. Also involved in corticospinal tract axon guidances independently of DCC. It also acts as a dependence receptor required for apoptosis induction when not associated with netrin ligand. {ECO:0000250|UniProtKB:O08747}.

Subcellular location: Cell membrane {ECO:0000250|UniProtKB:O08747}; Single-pass type I membrane protein {ECO:0000250|UniProtKB:O08747}. Cell junction, synapse, synaptosome {ECO:0000250|UniProtKB:Q761X5}.

Transmembrane domains:

  1. 381-401, 21 AA, Helical. {ECO:0000255}.

Sequence: 931 AA

10 20 30 40 50 60 MRKGLRATAA RCGLGLGYLL QMLVLPALAL LSASGTGSAA QDDDFFHELP ETFPSDPPEP 70 80 90 100 110 120 LPHFLIEPEE AYIVKNKPVN LYCKASPATQ IYFKCNSEWV HQKDHIVDER VDETSGLIVR 130 140 150 160 170 180 EVSIEISRQQ VEELFGPEDY WCQCVAWSSA GTTKSRKAYV RIAYLRKTFE QEPLGKEVSL 190 200 210 220 230 240 EQEVLLQCRP PEGIPVAEVE WLKNEDIIDP VEDRNFYITI DHNLIIKQAR LSDTANYTCV 250 260 270 280 290 300 AKNIVAKRKS TTATVIVYVN GGWSTWTEWS VCNSRCGRGY QKRTRTCTNP APLNGGAFCE 310 320 330 340 350 360 GQSVQKIACT TLCPVDGRWT PWSKWSTCGT ECTHWRRREC TAPAPKNGGK DCDGLVLQSK 370 380 390 400 410 420 NCTDGLCMQT APDSDDVALY VGIVIAVIVC LAISVVVALF VYRKNHRDFE SDIIDSSALN 430 440 450 460 470 480 GGFQPVNIKA ARQDLLAVPP DLTSAAAMYR GPVYALHDVS DKIPMTNSPI LDPLPNLKIK 490 500 510 520 530 540 VYNTSGAVTP QDDLSEFTSK LSPQMTQSLL ENEALSLKNQ SLARQTDPSC TAFGSFNSLG 550 560 570 580 590 600 GHLIVPNSGV SLLIPAGAIP QGRVYEMYVT VHRKETMRPP MDDSQTLLTP VVSCGPPGAL 610 620 630 640 650 660 LTRPVVLTMH HCADPNTEDW KILLKNQAAQ GQWEDVVVVG EENFTTPCYI QLDAEACHIL 670 680 690 700 710 720 TENLSTYALV GHSTTKAAAK RLKLAIFGPL CCSSLEYSIR VYCLDDTQDA LKEILHLERQ 730 740 750 760 770 780 MGGQLLEEPK ALHFKGSTHN LRLSIHDIAH SLWKSKLLAK YQEIPFYHVW SGSQRNLHCT 790 800 810 820 830 840 FTLERFSLNT VELVCKLCVR QVEGEGQIFQ LNCTVSEEPT GIDLPLLDPA NTITTVTGPS 850 860 870 880 890 900 AFSIPLPIRQ KLCSSLDAPQ TRGHDWRMLA HKLNLDRYLN YFATKSSPTG VILDLWEAQN 910 920 930 FPDGNLSMLA AVLEEMGRHE TVVSLAAEGQ Y

CATM prediction

The sequence of UNC5C_HUMAN returned 1 potential models

The positions at the dimer's interface are highlighted in yellow. The position at the crossing point is highlighted in orange.

# Sequence and interface d θ Z' ω' Score
    380       390       400  
  |    +    |    +    |    		 (Å) (°) (Å) (°)  
Model 1 ALYVGIVIAVIVCLAISVVVALFVYRK 7.3 -40.0° 4.5 44.0 -6.1

Click on the model number to visualize its details below.

MODEL 1 DETAILS

Precited structure:


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Download model 1 structure: PDB, PyMOL session