NADH dehydrogenase [ubiquinone] 1 beta subcomplex subunit 8, mitochondrial

UniProt data

UniProt name: NDUB8_HUMAN (O95169)

Gene name: NDUFB8

Organism: Homo sapiens (Human).

Function: Accessory subunit of the mitochondrial membrane respiratory chain NADH dehydrogenase (Complex I), that is believed not to be involved in catalysis. Complex I functions in the transfer of electrons from NADH to the respiratory chain. The immediate electron acceptor for the enzyme is believed to be ubiquinone.

Subcellular location: Mitochondrion inner membrane; Single-pass membrane protein; Matrix side.

Transmembrane domains:

  1. 133-153, 21 AA, Helical. {ECO:0000255}.

Sequence: 186 AA

10 20 30 40 50 60 MAVARAGVLG VQWLQRASRN VMPLGARTAS HMTKDMFPGP YPRTPEERAA AAKKYNMRVE 70 80 90 100 110 120 DYEPYPDDGM GYGDYPKLPD RSQHERDPWY SWDQPGLRLN WGEPMHWHLD MYNRNRVDTS 130 140 150 160 170 180 PTPVSWHVMC MQLFGFLAFM IFMCWVGDVY PVYQPVGPKQ YPYNNLYLER GGDPSKEPER VVHYEI

CATM prediction

The sequence of NDUB8_HUMAN returned 2 potential models

The positions at the dimer's interface are highlighted in yellow. The position at the crossing point is highlighted in orange.

# Sequence and interface d θ Z' ω' Score
  130       140       150    
|    +    |    +    |    + 		 (Å) (°) (Å) (°)  
Model 1 CMQLFGFLAFMIFMCWVGDVYAVYQAV 7.5 -46.2° 2.7 47.1 -31.6
Model 2 CMQLFGFLAFMIFMCWVGDVYAVYQAV 7.2 -36.9° 2.3 35.6 -17.1
Prolines* CMQLFGFLAFMIFMCWVGDVYPVYQPV          

* Note: this sequence contains Pro residues. CATM substituted them with Ala during the modeling. The positions are marked.

Click on the model number to visualize its details below.

MODEL 1 DETAILS

Precited structure:


Click on the image to enlarge

Download model 1 structure: PDB, PyMOL session

List of hydrogen bonds:

Donor Acceptor Distance
B, 144, CYS, HA A, 143, MET, O 3.47Å
B, 147, GLY, HA1 A, 144, CYS, O 3.47Å
A, 144, CYS, HA B, 143, MET, O 3.47Å
A, 147, GLY, HA1 B, 144, CYS, O 3.47Å