Tumor necrosis factor ligand superfamily member 15

UniProt data

UniProt name: TNF15_HUMAN (O95150)

Gene name: TNFSF15; Synonyms=TL1, VEGI

Organism: Homo sapiens (Human).

Function: Receptor for TNFRSF25 and TNFRSF6B. Mediates activation of NF-kappa-B. Inhibits vascular endothelial growth and angiogenesis (in vitro). Promotes activation of caspases and apoptosis. {ECO:0000269|PubMed:10597252, ECO:0000269|PubMed:11911831, ECO:0000269|PubMed:11923219, ECO:0000269|PubMed:9872942}.

Subcellular location: Tumor necrosis factor ligand superfamily member 15, secreted form: Secreted.

Transmembrane domains:

  1. 36-56, 21 AA, Helical; Signal-anchor for type II membrane protein. {ECO:0000255}.

Sequence: 251 AA

10 20 30 40 50 60 MAEDLGLSFG ETASVEMLPE HGSCRPKARS SSARWALTCC LVLLPFLAGL TTYLLVSQLR 70 80 90 100 110 120 AQGEACVQFQ ALKGQEFAPS HQQVYAPLRA DGDKPRAHLT VVRQTPTQHF KNQFPALHWE 130 140 150 160 170 180 HELGLAFTKN RMNYTNKFLL IPESGDYFIY SQVTFRGMTS ECSEIRQAGR PNKPDSITVV 190 200 210 220 230 240 ITKVTDSYPE PTQLLMGTKS VCEVGSNWFQ PIYLGAMFSL QEGDKLMVNV SDISLVDYTK 250 EDKTFFGAFL L

CATM prediction

The sequence of TNF15_HUMAN returned 1 potential models

The positions at the dimer's interface are highlighted in yellow. The position at the crossing point is highlighted in orange.

# Sequence and interface d θ Z' ω' Score
         40        50        
  +    |    +    |    +    		 (Å) (°) (Å) (°)  
Model 1 ARWALTCCLVLLAFLAGLTTYLLVSQL 7.3 -54.2° 2.9 50.7 -15.2
Prolines* ARWALTCCLVLLPFLAGLTTYLLVSQL          

* Note: this sequence contains Pro residues. CATM substituted them with Ala during the modeling. The positions are marked.

Click on the model number to visualize its details below.

MODEL 1 DETAILS

Precited structure:


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Download model 1 structure: PDB, PyMOL session

List of hydrogen bonds:

Donor Acceptor Distance
B, 46, PHE, HA A, 45, ALA, O 3.42Å
B, 49, GLY, HA1 A, 46, PHE, O 3.33Å
A, 46, PHE, HA B, 45, ALA, O 3.42Å
A, 49, GLY, HA1 B, 46, PHE, O 3.33Å