Neurofascin

UniProt data

UniProt name: NFASC_HUMAN (O94856)

Gene name: NFASC; Synonyms=KIAA0756

Organism: Homo sapiens (Human).

Function: Cell adhesion, ankyrin-binding protein which may be involved in neurite extension, axonal guidance, synaptogenesis, myelination and neuron-glial cell interactions. {ECO:0000250}.

Subcellular location: Cell membrane; Single-pass type I membrane protein.

Transmembrane domains:

  1. 1218-1238, 21 AA, Helical. {ECO:0000255}.

Sequence: 1347 AA

10 20 30 40 50 60 MARQPPPPWV HAAFLLCLLS LGGAIEIPMD PSIQNELTQP PTITKQSAKD HIVDPRDNIL 70 80 90 100 110 120 IECEAKGNPA PSFHWTRNSR FFNIAKDPRV SMRRRSGTLV IDFRSGGRPE EYEGEYQCFA 130 140 150 160 170 180 RNKFGTALSN RIRLQVSKSP LWPKENLDPV VVQEGAPLTL QCNPPPGLPS PVIFWMSSSM 190 200 210 220 230 240 EPITQDKRVS QGHNGDLYFS NVMLQDMQTD YSCNARFHFT HTIQQKNPFT LKVLTTRGVA 250 260 270 280 290 300 ERTPSFMYPQ GTASSQMVLR GMDLLLECIA SGVPTPDIAW YKKGGDLPSD KAKFENFNKA 310 320 330 340 350 360 LRITNVSEED SGEYFCLASN KMGSIRHTIS VRVKAAPYWL DEPKNLILAP GEDGRLVCRA 370 380 390 400 410 420 NGNPKPTVQW MVNGEPLQSA PPNPNREVAG DTIIFRDTQI SSRAVYQCNT SNEHGYLLAN 430 440 450 460 470 480 AFVSVLDVPP RMLSPRNQLI RVILYNRTRL DCPFFGSPIP TLRWFKNGQG SNLDGGNYHV 490 500 510 520 530 540 YENGSLEIKM IRKEDQGIYT CVATNILGKA ENQVRLEVKD PTRIYRMPED QVARRGTTVQ 550 560 570 580 590 600 LECRVKHDPS LKLTVSWLKD DEPLYIGNRM KKEDDSLTIF GVAERDQGSY TCVASTELDQ 610 620 630 640 650 660 DLAKAYLTVL ADQATPTNRL AALPKGRPDR PRDLELTDLA ERSVRLTWIP GDANNSPITD 670 680 690 700 710 720 YVVQFEEDQF QPGVWHDHSK YPGSVNSAVL RLSPYVNYQF RVIAINEVGS SHPSLPSERY 730 740 750 760 770 780 RTSGAPPESN PGDVKGEGTR KNNMEITWTP MNATSAFGPN LRYIVKWRRR ETREAWNNVT 790 800 810 820 830 840 VWGSRYVVGQ TPVYVPYEIR VQAENDFGKG PEPESVIGYS GEDYPRAAPT EVKVRVMNST 850 860 870 880 890 900 AISLQWNRVY SDTVQGQLRE YRAYYWRESS LLKNLWVSQK RQQASFPGDR LRGVVSRLFP 910 920 930 940 950 960 YSNYKLEMVV VNGRGDGPRS ETKEFTTPEG VPSAPRRFRV RQPNLETINL EWDHPEHPNG 970 980 990 1000 1010 1020 IMIGYTLKYV AFNGTKVGKQ IVENFSPNQT KFTVQRTDPV SRYRFTLSAR TQVGSGEAVT 1030 1040 1050 1060 1070 1080 EESPAPPNEA TPTAAPPTLP PTTVGATGAV SSTDATAIAA TTEATTVPII PTVAPTTIAT 1090 1100 1110 1120 1130 1140 TTTVATTTTT TAAATTTTES PPTTTSGTKI HESAPDEQSI WNVTVLPNSK WANITWKHNF 1150 1160 1170 1180 1190 1200 GPGTDFVVEY IDSNHTKKTV PVKAQAQPIQ LTDLYPGMTY TLRVYSRDNE GISSTVITFM 1210 1220 1230 1240 1250 1260 TSTAYTNNQA DIATQGWFIG LMCAIALLVL ILLIVCFIKR SRGGKYPVRE KKDVPLGPED 1270 1280 1290 1300 1310 1320 PKEEDGSFDY SDEDNKPLQG SQTSLDGTIK QQESDDSLVD YGEGGEGQFN EDGSFIGQYT 1330 1340 VKKDKEETEG NESSEATSPV NAIYSLA

CATM prediction

The sequence of NFASC_HUMAN returned 2 potential models

The positions at the dimer's interface are highlighted in yellow. The position at the crossing point is highlighted in orange.

# Sequence and interface d θ Z' ω' Score
       1220      1230      12
+    |    +    |    +    | 		 (Å) (°) (Å) (°)  
Model 1 QGWFIGLMCAIALLVLILLIVCFIKRS 6.7 -40.0° 5.1 44.0 -15.5
Model 2 QGWFIGLMCAIALLVLILLIVCFIKRS 6.6 -51.0° 6.0 45.0 -3.4

Click on the model number to visualize its details below.

MODEL 1 DETAILS

Precited structure:


Click on the image to enlarge

Download model 1 structure: PDB, PyMOL session