Mitochondrial import receptor subunit TOM70

UniProt data

UniProt name: TOM70_HUMAN (O94826)

Gene name: TOMM70 {ECO:0000312|HGNC:HGNC:11985}

Organism: Homo sapiens (Human).

Function: Receptor that accelerates the import of all mitochondrial precursor proteins. {ECO:0000250}.

Subcellular location: Mitochondrion outer membrane {ECO:0000250}; Single-pass membrane protein {ECO:0000250}.

Transmembrane domains:

  1. 39-59, 21 AA, Helical. {ECO:0000255}.

Sequence: 608 AA

10 20 30 40 50 60 MAASKPVEAA VVAAAVPSSG SGVGGGGTAG PGTGGLPRWQ LALAVGAPLL LGAGAIYLWS 70 80 90 100 110 120 RQQRRREARG RGDASGLKRN SERKTPEGRA SPAPGSGHPE GPGAHLDMNS LDRAQAAKNK 130 140 150 160 170 180 GNKYFKAGKY EQAIQCYTEA ISLCPTEKNV DLSTFYQNRA AAFEQLQKWK EVAQDCTKAV 190 200 210 220 230 240 ELNPKYVKAL FRRAKAHEKL DNKKECLEDV TAVCILEGFQ NQQSMLLADK VLKLLGKEKA 250 260 270 280 290 300 KEKYKNREPL MPSPQFIKSY FSSFTDDIIS QPMLKGEKSD EDKDKEGEAL EVKENSGYLK 310 320 330 340 350 360 AKQYMEEENY DKIISECSKE IDAEGKYMAE ALLLRATFYL LIGNANAAKP DLDKVISLKE 370 380 390 400 410 420 ANVKLRANAL IKRGSMYMQQ QQPLLSTQDF NMAADIDPQN ADVYHHRGQL KILLDQVEEA 430 440 450 460 470 480 VADFDECIRL RPESALAQAQ KCFALYRQAY TGNNSSQIQA AMKGFEEVIK KFPRCAEGYA 490 500 510 520 530 540 LYAQALTDQQ QFGKADEMYD KCIDLEPDNA TTYVHKGLLQ LQWKQDLDRG LELISKAIEI 550 560 570 580 590 600 DNKCDFAYET MGTIEVQRGN MEKAIDMFNK AINLAKSEME MAHLYSLCDA AHAQTEVAKK YGLKPPTL

CATM prediction

The sequence of TOM70_HUMAN returned 2 potential models

The positions at the dimer's interface are highlighted in yellow. The position at the crossing point is highlighted in orange.

# Sequence and interface d θ Z' ω' Score
      40        50        60 
    |    +    |    +    |  		 (Å) (°) (Å) (°)  
Model 1 LARWQLALAVGAALLLGAGAIYLWSRQ 6.5 -55.4° 2.4 48.2 -11.9
Model 2 LARWQLALAVGAALLLGAGAIYLWSRQ 7.3 -51.2° 3.3 47.9 -3.0
Prolines* LPRWQLALAVGAPLLLGAGAIYLWSRQ          

* Note: this sequence contains Pro residues. CATM substituted them with Ala during the modeling. The positions are marked.

Click on the model number to visualize its details below.

MODEL 1 DETAILS

Precited structure:


Click on the image to enlarge

Download model 1 structure: PDB, PyMOL session

List of hydrogen bonds:

Donor Acceptor Distance
B, 43, LEU, HA A, 42, ALA, O 2.85Å
B, 46, GLY, HA1 A, 43, LEU, O 2.59Å
A, 43, LEU, HA B, 42, ALA, O 2.85Å
A, 46, GLY, HA1 B, 43, LEU, O 2.59Å