Protein JTB

UniProt data

UniProt name: JTB_HUMAN (O76095)

Gene name: JTB; ORFNames=HSPC222

Organism: Homo sapiens (Human).

Function: Required for normal cytokinesis during mitosis. Plays a role in the regulation of cell proliferation. May be a component of the chromosomal passenger complex (CPC), a complex that acts as a key regulator of mitosis. The CPC complex has essential functions at the centromere in ensuring correct chromosome alignment and segregation and is required for chromatin-induced microtubule stabilization and spindle assembly. Increases AURKB activity. Inhibits apoptosis induced by TGFB1 (By similarity). Overexpression induces swelling of mitochondria and reduces mitochondrial membrane potential (By similarity). {ECO:0000250, ECO:0000269|PubMed:21225229}.

Subcellular location: Membrane {ECO:0000305}; Single-pass type I membrane protein {ECO:0000305}. Mitochondrion {ECO:0000250}. Cytoplasm. Cytoplasm, cytoskeleton, microtubule organizing center, centrosome. Cytoplasm, cytoskeleton, spindle. Note=Detected at the centrosome and along spindle fibers during prophase and metaphase. Detected at the midbody during telophase.

Transmembrane domains:

  1. 106-126, 21 AA, Helical. {ECO:0000255}.

Sequence: 146 AA

10 20 30 40 50 60 MLAGAGRPGL PQGRHLCWLL CAFTLKLCQA EAPVQEEKLS ASTSNLPCWL VEEFVVAEEC 70 80 90 100 110 120 SPCSNFRAKT TPECGPTGYV EKITCSSSKR NEFKSCRSAL MEQRLFWKFE GAVVCVALIF 130 140 ACLVIIRQRQ LDRKALEKVR KQIESI

CATM prediction

The sequence of JTB_HUMAN returned 1 potential models

The positions at the dimer's interface are highlighted in yellow. The position at the crossing point is highlighted in orange.

# Sequence and interface d θ Z' ω' Score
         110       120       
  +    |    +    |    +    		 (Å) (°) (Å) (°)  
Model 1 QRLFWKFEGAVVCVALIFACLVIIRQR 6.9 -53.1° 2.0 45.0 -8.5

Click on the model number to visualize its details below.

MODEL 1 DETAILS

Precited structure:


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Download model 1 structure: PDB, PyMOL session

List of hydrogen bonds:

Donor Acceptor Distance
B, 108, LYS, HA A, 107, TRP, O 3.21Å
B, 111, GLY, HA1 A, 108, LYS, O 2.87Å
A, 108, LYS, HA B, 107, TRP, O 3.21Å
A, 111, GLY, HA1 B, 108, LYS, O 2.87Å