Carboxypeptidase D

UniProt data

UniProt name: CBPD_HUMAN (O75976)

Gene name: CPD

Organism: Homo sapiens (Human).

Function:

Subcellular location: Cell membrane {ECO:0000250|UniProtKB:Q90240}; Single-pass type I membrane protein {ECO:0000255}.

Transmembrane domains:

  1. 1300-1320, 21 AA, Helical. {ECO:0000255}.

Sequence: 1380 AA

10 20 30 40 50 60 MASGRDERPP WRLGRLLLLM CLLLLGSSAR AAHIKKAEAT TTTTSAGAEA AEGQFDRYYH 70 80 90 100 110 120 EEELESALRE AAAAGLPGLA RLFSIGRSVE GRPLWVLRLT AGLGSLIPEG DAGPDAAGPD 130 140 150 160 170 180 AAGPLLPGRP QVKLVGNMHG DETVSRQVLI YLARELAAGY RRGDPRLVRL LNTTDVYLLP 190 200 210 220 230 240 SLNPDGFERA REGDCGFGDG GPSGASGRDN SRGRDLNRSF PDQFSTGEPP ALDEVPEVRA 250 260 270 280 290 300 LIEWIRRNKF VLSGNLHGGS VVASYPFDDS PEHKATGIYS KTSDDEVFKY LAKAYASNHP 310 320 330 340 350 360 IMKTGEPHCP GDEDETFKDG ITNGAHWYDV EGGMQDYNYV WANCFEITLE LSCCKYPPAS 370 380 390 400 410 420 QLRQEWENNR ESLITLIEKV HIGVKGFVKD SITGSGLENA TISVAGINHN ITTGRFGDFY 430 440 450 460 470 480 RLLVPGTYNL TVVLTGYMPL TVTNVVVKEG PATEVDFSLR PTVTSVIPDT TEAVSTASTV 490 500 510 520 530 540 AIPNILSGTS SSYQPIQPKD FHHHHFPDME IFLRRFANEY PNITRLYSLG KSVESRELYV 550 560 570 580 590 600 MEISDNPGVH EPGEPEFKYI GNMHGNEVVG RELLLNLIEY LCKNFGTDPE VTDLVHNTRI 610 620 630 640 650 660 HLMPSMNPDG YEKSQEGDSI SVIGRNNSNN FDLNRNFPDQ FVQITDPTQP ETIAVMSWMK 670 680 690 700 710 720 SYPFVLSANL HGGSLVVNYP FDDDEQGLAT YSKSPDDAVF QQIALSYSKE NSQMFQGRPC 730 740 750 760 770 780 KNMYPNEYFP HGITNGASWY NVPGGMQDWN YLQTNCFEVT IELGCVKYPL EKELPNFWEQ 790 800 810 820 830 840 NRRSLIQFMK QVHQGVRGFV LDATDGRGIL NATISVAEIN HPVTTYKTGD YWRLLVPGTY 850 860 870 880 890 900 KITASARGYN PVTKNVTVKS EGAIQVNFTL VRSSTDSNNE SKKGKGASSS TNDASDPTTK 910 920 930 940 950 960 EFETLIKDLS AENGLESLML RSSSNLALAL YRYHSYKDLS EFLRGLVMNY PHITNLTNLG 970 980 990 1000 1010 1020 QSTEYRHIWS LEISNKPNVS EPEEPKIRFV AGIHGNAPVG TELLLALAEF LCLNYKKNPA 1030 1040 1050 1060 1070 1080 VTQLVDRTRI VIVPSLNPDG RERAQEKDCT SKIGQTNARG KDLDTDFTNN ASQPETKAII 1090 1100 1110 1120 1130 1140 ENLIQKQDFS LSVALDGGSM LVTYPYDKPV QTVENKETLK HLASLYANNH PSMHMGQPSC 1150 1160 1170 1180 1190 1200 PNKSDENIPG GVMRGAEWHS HLGSMKDYSV TYGHCPEITV YTSCCYFPSA ARLPSLWADN 1210 1220 1230 1240 1250 1260 KRSLLSMLVE VHKGVHGFVK DKTGKPISKA VIVLNEGIKV QTKEGGYFHV LLAPGVHNII 1270 1280 1290 1300 1310 1320 AIADGYQQQH SQVFVHHDAA SSVVIVFDTD NRIFGLPREL VVTVSGATMS ALILTACIIW 1330 1340 1350 1360 1370 CICSIKSNRH KDGFHRLRQH HDEYEDEIRM MSTGSKKSLL SHEFQDETDT EEETLYSSKH

CATM prediction

The sequence of CBPD_HUMAN returned 1 potential models

The positions at the dimer's interface are highlighted in yellow. The position at the crossing point is highlighted in orange.

# Sequence and interface d θ Z' ω' Score
     1300      1310      1320
   |    +    |    +    |   		 (Å) (°) (Å) (°)  
Model 1 ARELVVTVSGATMSALILTACIIWCIC 6.8 -55.1° 1.5 44.9 -12.5
Prolines* PRELVVTVSGATMSALILTACIIWCIC          

* Note: this sequence contains Pro residues. CATM substituted them with Ala during the modeling. The positions are marked.

Click on the model number to visualize its details below.

MODEL 1 DETAILS

Precited structure:


Click on the image to enlarge

Download model 1 structure: PDB, PyMOL session

List of hydrogen bonds:

Donor Acceptor Distance
B, 1303, THR, HA A, 1302, VAL, O 3.33Å
B, 1306, GLY, HA1 A, 1303, THR, O 2.75Å
B, 1307, ALA, HA A, 1306, GLY, O 3.34Å
A, 1303, THR, HA B, 1302, VAL, O 3.33Å
A, 1306, GLY, HA1 B, 1303, THR, O 2.75Å
A, 1307, ALA, HA B, 1306, GLY, O 3.34Å
A, 1307, ALA, HA B, 1310, SER, OG 2.94Å