UniProt data
UniProt name: CEAM4_HUMAN (O75871)
Gene name: CEACAM4; Synonyms=CGM7
Organism: Homo sapiens (Human).
Function: Granulocyte orphan receptor that acts as an trigger efficient phagocytosis of attached particles. {ECO:0000269|PubMed:25567962}.
Subcellular location: Membrane; Single-pass type I membrane protein.
Transmembrane domains:
- 156-176, 21 AA, Helical. {ECO:0000255}.
Sequence: 244 AA
10 20 30 40 50 60
MGPPSAAPRG GHRPWQGLLI TASLLTFWHP PTTVQFTIEA LPSSAAEGKD VLLLACNISE
70 80 90 100 110 120
TIQAYYWHKG KTAEGSPLIA GYITDIQANI PGAAYSGRET VYPNGSLLFQ NITLEDAGSY
130 140 150 160 170 180
TLRTINASYD SDQATGQLHV HQNNVPGLPV GAVAGIVTGV LVGVALVAAL VCFLLLSRTG
190 200 210 220 230 240
RASIQRDLRE QPPPASTPGH GPSHRSTFSA PLPSPRTATP IYEELLYSDA NIYCQIDHKA
DVVS
CATM prediction
The sequence of CEAM4_HUMAN returned 4 potential models
The positions at the dimer's interface are highlighted in yellow. The position at the crossing point is highlighted in orange.
| # | Sequence and interface | d | θ | Z' | ω' | Score |
|---|---|---|---|---|---|---|
| 160 170 + | + | + |
(Å) | (°) | (Å) | (°) | ||
| Model 1 | VAGIVTGVLVGVALVAALVCFLLLSRT | 6.3 | -45.2° | 2.7 | 61.0 | -30.5 |
| Model 2 | VAGIVTGVLVGVALVAALVCFLLLSRT | 6.8 | -25.0° | 5.5 | 50.0 | -29.6 |
| Model 3 | VAGIVTGVLVGVALVAALVCFLLLSRT | 7.0 | -52.8° | 4.2 | 53.7 | -17.0 |
| Model 4 | VAGIVTGVLVGVALVAALVCFLLLSRT | 6.5 | -53.0° | 5.2 | 58.0 | -12.8 |
Click on the model number to visualize its details below.
MODEL 1 DETAILS
Precited structure:
Click on the image to enlarge
Download model 1 structure: PDB, PyMOL session
List of hydrogen bonds:
| Donor | Acceptor | Distance |
|---|---|---|
| B, 159, GLY, HA1 | A, 156, ILE, O | 2.66Å |
| B, 160, VAL, HA | A, 159, GLY, O | 3.25Å |
| A, 159, GLY, HA1 | B, 156, ILE, O | 2.66Å |
| A, 160, VAL, HA | B, 159, GLY, O | 3.25Å |
